Risk factors for ganciclovir-induced thrombocytopenia and leukopenia

Biological & Pharmaceutical Bulletin
Kazuaki MatsumotoYasuo Takeda

Abstract

Ganciclovir is a nucleoside guanosine analogue that exhibits therapeutic activity against human cytomegalovirus infection, and is primarily excreted via glomerular filtration and active tubular secretion. The adverse effects induced by ganciclovir therapy are generally of a hematological nature and include thrombocytopenia and leukopenia. Low marrow cellularity and elevated serum creatinine have been identified as risk factors for ganciclovir-induced neutropenia. However, the risk factors for thrombocytopenia have yet to be determined. Therefore, this study investigated patients administered ganciclovir to determine the risk factors for thrombocytopenia and leukopenia. Thrombocytopenia occurred in 41 of these patients (30.6%). Multivariate logistic regression analysis identified three independent risk factors for thrombocytopenia: cancer chemotherapy (odds ratio (OR)=3.1), creatinine clearance (<20 mL/min) (OR=12.8), and the ganciclovir dose (≥12 mg/kg/d) (OR=15.1). Leukopenia occurred in 36 patients (28.6%), and white blood cell count (<6000 cells/mm(3)) (OR=3.7) and the ganciclovir dose (≥12 mg/kg/d) (OR=7.8) were identified as risk factors. These results demonstrated that several factors influenced the occurrence of ganciclo...Continue Reading

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Citations

Jul 13, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Pierre-André BillatNicolas Picard
Nov 30, 2018·Frontiers in Pharmacology·Antony Brayan Campos-SalazarRosario Dominguez Crespo Hirata
Nov 26, 2015·World Journal of Gastroenterology : WJG·Jun-Yan QianJia-Ming Qian
Nov 7, 2017·American Journal of Clinical Pathology·Isaac H SolomonAlvaro C Laga

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