Risk Factors for Gastric Tumorigenesis in Underlying Gastric Mucosal Atrophy

Gut and Liver
Ji Hyun SongSun Young Yang

Abstract

Atrophic gastritis is considered a premalignant lesion. We aimed to evaluate the risk factors for gastric tumorigenesis in underlying mucosal atrophy. A total of 10,185 subjects who underwent upper gastrointestinal endoscopy between 2003 and 2004 were enrolled in this retrospective cohort study. Follow-up endoscopy was performed between 2005 and 2014. Atrophic gastritis and intestinal metaplasia were assessed by endoscopy using the Kimura-Takemoto classification. Helicobacter pylori infection was evaluated based on serum immunoglobulin G antibody levels, the rapid urease test, or the urea breath test. Atrophic gastritis was confirmed in 3,714 patients at baseline; 2,144 patients were followed up for 6.9 years, and 1,138 exhibited increased atrophy. A total of 69 subjects were diagnosed with gastric neoplasm during follow-up (35 adenoma and 34 carcinoma). Age ≥55 years (hazard ratio [HR], 1.234), alcohol consumption (HR, 1.001), and H. pylori infection (HR, 1.580) were associated with increased mucosal atrophy. The risk factors for gastric neoplasm in underlying mucosal atrophy were age ≥55 years (HR, 2.582), alcohol consumption (HR, 1.003), extent of mucosal atrophy (HR, 2.285 in C3-O1; HR, 4.187 in O2-O3), and intestinal metap...Continue Reading

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Citations

Jul 3, 2019·Journal of Endocrinological Investigation·V CalcaterraD Larizza
Jun 28, 2018·F1000Research·William WaddinghamMarnix Jansen
Jan 29, 2019·World Journal of Gastroenterology : WJG·Jung Hwan YoonWon Sang Park
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Aug 17, 2019·Molecular Cancer Research : MCR·Sang Il ChoiSoo-Jeong Cho
Sep 16, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kyungeun KimSeungho Ryu
May 11, 2021·World Journal of Clinical Cases·Sergey M KotelevetsSergey Z Chukov
Jul 29, 2021·Gastroenterology Report·Daniela Cornelia LazărAdrian Goldiş

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Methods Mentioned

BETA
biopsy
enzyme-linked immunosorbent assay
biopsies

Software Mentioned

SPSS

Related Concepts

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Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.