Risk factors for graft loss in patients with recurrent IGA nephropathy after renal transplantation

Transplantation Proceedings
Y NambaS Takahara

Abstract

The recurrence rate of IgA nephropathy (IgAN) in transplanted kidneys has been reported to be >50%. Although recurrent IgAN has a benign clinical course, recent data suggest that it leads to graft loss in a substantial number of patients. We performed a retrospective single-center analysis of 34 renal transplant recipients, with biopsy-proven IgAN as the cause of end-stage renal failure. Renal allograft biopsies were performed in 30 patients, of whom 24 did and 6 did not have biopsy-confirmed recurrent transplant IgAN. Recurrent transplant IgAN was more often detected in men and at later timepoints after post-transplantation. Four patients with recurrent transplant IgAN progressed to graft failure. Progression to graft failure was associated with worsened renal function, higher systolic blood pressure, and the lack of presenation of angiotensin-converting enzyme inhibitors (ACEs) at the time of allograft biopsy. Immunologic factors such as frequency of acute rejection, HLA typing, and immunosuppression did not show a relation to recurrence or graft loss. Recurrent transplant IgAN increased with long-term graft survival and risk factors for graft loss due to recurrent IgAN were similar to those among IgAN in native kidneys.

References

Aug 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J M BrensilverR McCabe
Jul 17, 1998·Transplant International : Official Journal of the European Society for Organ Transplantation·M KyoA Okuyama
Sep 15, 1999·Clinical Transplantation·P FreeseG Nyberg
May 16, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·K OkaS Takahara
Nov 13, 2001·Kidney International·C PonticelliA Tarantino
Jul 3, 2003·Seminars in Nephrology·Arjang DjamaliJohn D Pirsch

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Citations

Jun 16, 2005·Clinical Transplantation·Shigeo HaraKeihachiro Kuzuhara
Apr 5, 2013·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Keitaro SatoKazunari Tanabe
Mar 1, 2006·Transplantation Proceedings·J PazikM Durlik
Apr 13, 2004·Oncogene·Klaus-Michael Debatin, Peter H Krammer
Sep 13, 2005·Oncogene·Fernando A ProiettiEdward L Murphy
Nov 8, 2008·American Journal of Respiratory Cell and Molecular Biology·Manasi N ShuklaPrabir Ray
Jul 18, 2009·Reproductive Medicine and Biology·Hidehiko Matsubayashi

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