Risk factors for Group B Streptococcus colonisation and disease in Gambian women and their infants

The Journal of Infection
Kirsty Le DoareB Kampmann

Abstract

To determine risk factors for GBS colonisation in Gambian mothers and in their infants from birth to day 60-89 of age. Swabs and breastmilk from mothers/infant pairs were collected and cultured on selective agar. Negative samples were analysed for GBS DNA via real-time PCR. Positive isolates were serotyped using multiplex PCR and gel-agarose electrophoresis. Seven hundred and fifty women/infant pairs were recruited. 253 women (33.7%) were GBS-colonised at delivery. The predominant serotypes were: V (55%), II (16%), III (10%), Ia (8%) and Ib (8%). 186 infants were colonised (24.8%) at birth, 181 (24.1%) at 6 days and 96 at day 60-89 (14%). Infants born before 34 weeks of gestation and to women with rectovaginal and breastmilk colonisation at delivery had increased odds of GBS colonisation at birth. Season of birth was associated with increased odds of persistent infant GBS colonisation (dry season vs. wet season AOR 2.9; 95% CI 1.6-5.2). GBS colonisation is common in Gambian women at delivery and in their infants to day 60-89 and is dominated by serotype V. In addition to maternal colonisation, breastmilk and season of birth are important risk factors for infant GBS colonisation.

References

Nov 1, 1994·The Journal of Infectious Diseases·R O SuaraB M Greenwood
Feb 1, 1996·The Journal of Infectious Diseases·H M BlumbergM M Farley
Oct 26, 1999·The Pediatric Infectious Disease Journal·E K MulhollandB M Greenwood
Jul 20, 2000·The New England Journal of Medicine·A Schuchat
Jan 11, 2007·Pediatric Research·David S Newburg, W Allan Walker
Dec 26, 2007·Acta Obstetricia Et Gynecologica Scandinavica·Stellan HåkanssonUNKNOWN Swedish Working Group For The Prevention of Perinatal Group B Streptococcal Infections
Dec 5, 2009·Journal of Microbiological Methods·Monica ImperiRoberta Creti
Dec 22, 2009·American Journal of Infection Control·Jennifer K MacFarquharWilliam Schaffner
May 25, 2011·Expert Review of Vaccines·Paul T Heath
Apr 24, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alemnew F DagnewSue Ann Costa Clemens
Jul 23, 2013·The Journal of Pediatrics·Alberto BerardiFabrizio Ferrari
Aug 21, 2013·Archives of Disease in Childhood. Fetal and Neonatal Edition·A FilleronH Marchandin
Sep 18, 2013·Early Human Development·F MonariF Facchinetti
Nov 30, 2013·Archives of Disease in Childhood·Alberto BerardiUNKNOWN GBS Prevention Working Group, Emilia-Romagna
Jan 29, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Mary MeehanMary Cafferkey
Feb 15, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·G KwatraS A Madhi
Jun 9, 2015·Paediatrics and International Child Health·Uduak A OkomoKalifa Bojang

❮ Previous
Next ❯

Citations

May 30, 2016·The Lancet Infectious Diseases·Kirsty Le Doare
Sep 3, 2016·Clinical & Translational Immunology·Nicholas J AndreasKirsty Mehring Le Doare
Nov 9, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lola MadridUNKNOWN Infant GBS Disease Investigator Group
Nov 9, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joy E LawnAnna C Seale
Mar 7, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elita JauneikaiteShiranee Sriskandan
Apr 5, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Asmaa TaziClaire Poyart
Mar 30, 2019·Annals of Clinical Microbiology and Antimicrobials·Mucheye GizachewBelay Tessema
Jan 21, 2019·Annals of Clinical Microbiology and Antimicrobials·Mucheye GizachewBelay Tessema
Feb 2, 2019·Frontiers in Pediatrics·Anja SasoKirsty Le Doare
Jul 19, 2019·Frontiers in Microbiology·Swaine L Chen
Nov 9, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Neal J RussellUNKNOWN GBS Maternal Colonization Investigator Group
Apr 5, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Merel N van KasselMerijn W Bijlsma
Mar 16, 2019·Microbiology Spectrum·Lawrence C Paoletti, Dennis L Kasper

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

GraphPad Prism
STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.