Abstract
The contribution of hepatitis B, hepatitis C, and excess alcohol intake to the development of hepatocellular carcinoma in Turkey was assessed. The study was conducted through a questionnaire sent to seven major medical referral centers in different regions of Turkey and is based on 207 patients seen in the period 1994-1997. Of the seven centers, two were located in West Turkey (54 patients), two were in Central Turkey (85 patients), and two were in south and southeast Turkey (68 patients). In 196 of the 207 patients (94.7%), there was a history of chronic liver disease, and in 180 patients (87%) liver cirrhosis was documented. Of the 207 patients, 116 (56%) had hepatitis B, 48 (23.2%) had hepatitis C, and 33 (15.9%) had a history of excess alcohol intake. Anti-delta testing was available in 69 of 116 patients with hepatitis B, and anti-HDV was positive in 13 of these patients (13/69, 18.8%). Of the 33 patients with a history of heavy alcohol intake, 18 had concomitant chronic viral hepatitis infection, and alcohol alone was the etiology of hepatocellular carcinoma in only 15 cases (7.2%). The distribution of etiologic factors was not homogenous in different geographical regions in Turkey. In central, south, and southeastern Tur...Continue Reading
Citations
Feb 11, 2005·Current Gastroenterology Reports·Shane J Mills, Stephen A Harrison
Jun 25, 2005·Journal of Medical Virology·Gülendam BozdayiA Mithat Bozdayi
Mar 15, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Halil DeğertekinCihan Yurdaydin
Jan 19, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Heiner Wedemeyer
Feb 11, 2011·World Journal of Hepatology·Olfa BahriSoumaya Benjelloun
Jul 12, 2018·Epidemiology and Infection·Raffaella RomeoGiovanna Loquercio
Oct 21, 2019·Archives of Virology·Ines DhifallahOlfa Bahri
Jan 7, 2010·Nature Reviews. Gastroenterology & Hepatology·Heiner Wedemeyer, Michael P Manns
May 27, 2016·Hepatitis Monthly·Seyed Moayed Alavian, Hossein Haghbin
Dec 8, 2019·International Journal of Environmental Research and Public Health·Ying WangYuantao Hao
Jun 15, 2006·World Journal of Gastroenterology : WJG·Cesar YaghiRaymond Sayegh
May 1, 2013·Expert Review of Anti-infective Therapy·Fulya Gunsar
Apr 26, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Alper CanAhmet Alacacioglu
Jan 14, 2012·Archives of Virology·Frédéric Le GalPaul Dény
Oct 18, 2013·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver (KASL)
Nov 29, 2014·Journal of Viral Hepatitis·R IdilmanC Yurdaydin
Apr 29, 2015·World Journal of Hepatology·Zaigham AbbasLubna Shazi
Dec 23, 2011·Journal of Viral Hepatitis·UNKNOWN Specialist Panel on Chronic Hepatitis B in the Middle East
Jul 14, 2016·Clinical Transplantation·Ramazan IdilmanYaman Tokat
Apr 14, 2017·PloS One·Hung Minh NguyenC-Thomas Bock
Mar 5, 2004·Journal of Viral Hepatitis·D Lavanchy
Aug 30, 2008·Japanese Journal of Clinical Oncology·Ahmet AlacaciogluUgur Yilmaz
Oct 19, 2006·Mediators of Inflammation·Huseyin AtasevenBilal Ustundag
Nov 27, 2019·Gastrointestinal Tumors·Yazid ChikhiMustapha Lahcene