Risk factors for human immunodeficiency virus among blood donors in Cameroon: evidence for the design of an Africa-specific donor history questionnaire

Transfusion
Claude Tayou TagnyEdward Murphy

Abstract

In sub-Saharan Africa improving the deferral of at-risk blood donors would be a cost-effective approach to reducing transfusion-transmitted human immunodeficiency virus (HIV) infections. We performed a pilot case-control study to identify the risk factors for HIV infection and to develop an adapted donor history questionnaire (DHQ) for sub-Saharan Africa. We recruited 137 HIV-positive donors (cases) and 256 HIV-negative donors (controls) and gathered risk factor data using audio computer-assisted self-interview. Variables with univariate associations were entered into a logistic regression model to assess independent associations. A scoring scheme to distinguish between HIV-positive and HIV-negative donors was developed using receiver operating characteristics curves. We identified 16 risk factors including sex with sex worker, past history or treatment for sexually transmitted infections, and having a partner who used injected or noninjected illegal drugs. Two novel risks were related to local behavior: polygamy (odds ratio [OR], 22.7; 95% confidence interval [CI], 5.9-86.7) and medical or grooming treatment on the street (OR, 1.8; 95% CI, 1.0-3.0). Using the 16 selected items the mean scores (>100) were 82.6 ± 6.7 (range, 53....Continue Reading

References

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May 9, 2014·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·L Kouegnigan RerambiahJ F Djoba Siawaya
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Jan 1, 2014·The Pan African Medical Journal·Jeff Maotela KabindaJef Van den Ende

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Citations

Aug 21, 2018·Vox Sanguinis·Claude T TagnyUNKNOWN Francophone Africa Network for Transfusion Medicine Research
Jan 10, 2020·Blood Research·Moslem Taheri SoodejaniFarzaneh Zolala
Jun 9, 2021·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·Moses SamjeClaude T Tagny

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