Risk factors for in-hospital mortality in patients with type 2 diabetes complicated by community-acquired Klebsiella pneumoniae bacteremia

Journal of the Formosan Medical Association = Taiwan Yi Zhi
Chung-Huei HuangYu-Yao Huang

Abstract

Patients with diabetes are at a high risk of infection-related morbidity and mortality. Klebsiella pneumoniae bacilli are prevalent among diabetic patients, especially in Asian populations. The present study aimed to identify risk factors for in-hospital mortality among diabetic patients complicated by community-acquired K. pneumoniae bacteremia. We evaluated the clinical characteristics of 341 Taiwanese type 2 diabetic patients who were treated for community-acquired K. pneumoniae bacteremia. We then analyzed outcome predictors, and in particular comorbidities and the site of infection. The overall in-hospital mortality rate was 14.1%. Comorbid cancer was the leading factor, accounting for 32.1% of all cases of mortality. Pulmonary infection, primary bacteremia, afebrile or shock presentation and low serum albumin level were risk factors for in-hospital mortality. Regardless of comorbidities, pulmonary infection [odds ratio (OR) 10.74, 95% confidence interval (CI) 2.02-57.09] and albumin level (OR 0.15, 95% CI 0.03-0.76) were the main risk predictors. The receiver operating characteristic curve indicated that a serum albumin level lower than 2.4 g/dL (71.1% sensitivity and 77.4% specificity) suggested a poor prognosis in the d...Continue Reading

References

Feb 1, 1991·Diabetes Care·L LeiboviciM Drucker
Aug 1, 1994·The Journal of Hospital Infection·K H LeeT K Lim
Dec 1, 1996·QJM : Monthly Journal of the Association of Physicians·A M YinnonB Rudensky
Jul 29, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D C Norman
Mar 19, 2002·Emerging Infectious Diseases·Wen-Chien KoVictor L Yu
Jul 29, 2004·Journal of the American Dietetic Association·M Patricia FuhrmanCharles M Mueller
Feb 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Reimar W ThomsenHenrik T Sørensen
May 25, 2006·The Journal of Clinical Endocrinology and Metabolism·Jung-Chung LinFeng-Yee Chang
Jun 30, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chi-Tai FangShan-Chwen Chang
Sep 11, 2007·Infectious Disease Clinics of North America·Smita GuptaNancy Khardori
Nov 9, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Wen-Liang YuYin-Ching Chuang
Jan 25, 2008·Emerging Infectious Diseases·Victor L YuUNKNOWN International Klebseilla Study Group
Oct 2, 2008·Emerging Infectious Diseases·Feng-Chiao TsaiJin-Town Wang
Mar 3, 2009·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chia-Lin HsuPan-Chyr Yang
Jun 16, 2009·BMC Infectious Diseases·Galo PeraltaFátima Mateos
Aug 25, 2009·The American Journal of Medicine·Bonnie L MeatherallKevin B Laupland
Jun 18, 2010·CA: a Cancer Journal for Clinicians·Edward GiovannucciDouglas Yee
Jul 1, 2010·Diabetes Care·Edward GiovannucciDouglas Yee
Aug 27, 2010·QJM : Monthly Journal of the Association of Physicians·T A Chowdhury
Mar 4, 2011·The New England Journal of Medicine·Sreenivasa Rao Kondapally SeshasaiUNKNOWN Emerging Risk Factors Collaboration
Jan 3, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P J LillieG D Barlow

❮ Previous
Next ❯

Citations

May 23, 2021·International Orthopaedics·Hsin-I ChienLee-Wei Chen
Aug 22, 2021·Journal of Diabetes Investigation·Shih-Yuan HungYu-Yao Huang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.