Risk factors for incident open-angle glaucoma: a population-based 20-year follow-up study

Acta Ophthalmologica
Curt Ekström

Abstract

To study the effect of potential risk factors on the development of open-angle glaucoma (OAG) in a population in which pseudoexfoliation (PEX) is a common finding. In 1984-1986, a population-based survey of 760 people aged 65-74 years was conducted in the municipality of Tierp, Sweden. From 1988 to 2006, a follow-up study of the 530 people with normal visual fields has been in progress. To increase the cohort, 273 ophthalmic outpatients were enroled. Reliable visual fields were available for 679 people, representing 6 126 person-years at risk. A time-weighted mean intraocular pressure (IOP) for all visits was calculated. Sixty-four subjects developed definite OAG, 29 of whom were exposed to PEX. Risk factors associated with OAG were higher age, a positive family history, increased IOP and PEX. The age-standardized rate ratio (SRR) was 14.8 times (95% confidence interval [CI] 7.92-27.8) greater in subjects with mean IOP ≥ 20 mmHg than in those with mean IOP <20 mmHg. When subjects with IOP < 20 mmHg at baseline were affected by PEX, the SRR increased 5.01-fold (95% CI 1.97-12.8), compared with the unaffected group. However, when mean IOP at follow-up was taken into account, there was no relationship between OAG and PEX as a dist...Continue Reading

References

Apr 1, 1996·Acta Ophthalmologica Scandinavica·C Ekström
Dec 31, 1998·Archives of Ophthalmology·R C WolfsP T de Jong
Feb 13, 2001·Survey of Ophthalmology·R Ritch, U Schlötzer-Schrehardt
Jan 10, 2002·Acta Ophthalmologica Scandinavica·K GrødumB Bengtsson
Jan 30, 2002·The British Journal of Ophthalmology·Paul J FosterGordon J Johnson
Jul 6, 2002·Archives of Ophthalmology·M Cristina LeskeAnselm Hennis
Oct 9, 2002·Archives of Ophthalmology·Anders HeijlUNKNOWN Early Manifest Glaucoma Trial Group
Aug 27, 2003·Investigative Ophthalmology & Visual Science·Anhchuong LeHugh R Taylor
Jun 15, 2007·Ophthalmology·Rogier P H M MüskensNomdo M Jansonius
Jul 17, 2007·Ophthalmology·M Cristina LeskeUNKNOWN BESs Study Group
Jul 12, 2008·Acta Ophthalmologica·Curt Ekström, Albert Alm
Aug 12, 2008·Ophthalmology·Boel BengtssonUNKNOWN EMGT Group
Sep 13, 2008·Acta Ophthalmologica·Curt Ekström

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Citations

Dec 21, 2013·The British Journal of Ophthalmology·Yemisi TakwoingiUNKNOWN Surveillance for Ocular Hypertension Study Group
Jun 23, 2015·Acta Ophthalmologica·Curt Ekström, Amelie Botling Taube
Jan 30, 2013·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Michele ReibaldiAntonio Longo
May 31, 2013·Acta Ophthalmologica·Yu X YouJost B Jonas
Jul 25, 2013·Acta Ophthalmologica·Curt Ekström, Lena Kilander
Mar 29, 2014·Acta Ophthalmologica·Rebecka Svensson, Curt Ekström
Oct 30, 2016·American Journal of Ophthalmology·Hae-Young Lopilly ParkChan Kee Park
Sep 22, 2018·Acta Ophthalmologica·Antti ViljanenEija Vesti
Jul 10, 2018·Medicine and Science in Sports and Exercise·Nathan F MeierSteven N Blair
Oct 2, 2019·Acta Ophthalmologica·Curt Ekström, Lovisa Winblad von Walter
Jul 25, 2020·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·UNKNOWN Deutsche Ophthalmologische Gesellschaft (DOG), UNKNOWN Berufsverband der Augenärzte Deutschlands e. V. (BVA)
Oct 24, 2020·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Alexander K SchusterEsther M Hoff Mann
Aug 10, 2020·Journal of Glaucoma·Ricardo A Paletta GuedesAlfredo Chaoubah
Apr 29, 2020·Deutsches Ärzteblatt International·Alexander K SchusterNorbert Pfeiffer
Apr 22, 2021·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Alexander K SchusterEsther M Hoffmann

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