Risk Factors for Indeterminate Outcome on Interferon Gamma Release Assay in Non-US-Born Persons Screened for Latent Tuberculosis Infection.

Open Forum Infectious Diseases
Jody C SharninghausenH Nina Kim

Abstract

Non-US-born individuals account for the majority of active tuberculosis (TB) in the United States. Interferon gamma release assay (IGRA) is the preferred diagnostic test for latent TB but can produce an indeterminate result. We investigated the prevalence and predictors of an indeterminate IGRA (IND-IGRA) in a diverse cohort of non-US-born individuals and evaluated outcomes after IND-IGRA. We identified patient age ≥18 years who had an outpatient IGRA between 2010 and 2017 in our health system and whose primary language was not English. We used univariate and multivariable logistic regression to examine the association of IND-IGRA with a variety of clinical factors. Of 3128 outpatients with ≥1 IGRA done, 33% were Asian, 30% Hispanic, and 29% black; 44% were men, and the median age was 50 years. An initial IND-IGRA occurred in 118 (3.8%; 95% confidence interval [CI], 3.1%-4.5%); notably, Asian race (55%) and rheumatologic conditions (25%) were prevalent in this group. In multivariable analysis, Asian race was independently associated with IND-IGRA (adjusted odds ratio [aOR], 2.9; 95% CI, 1.9-4.3), in addition to the presence of anemia and hypoalbuminemia (aOR for interaction, 4.3; 95% CI, 1.3-14.3). Only 55% of patients with an ...Continue Reading

References

May 14, 2005·Emerging Infectious Diseases·Ted Cohen, Megan Murray
Jun 18, 2005·American Journal of Respiratory and Critical Care Medicine·Giovanni FerraraLuca Richeldi
Sep 28, 2007·European Journal of Immunology·Teresa ZelanteLuigina Romani
Sep 11, 2008·Scandinavian Journal of Immunology·J WalldénUNKNOWN ABIS Study Group
Jun 29, 2010·Arthritis and Rheumatism·Jan LeipeAlla Skapenko
Feb 15, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhong-Hua LinShi-Ying Xuan
Mar 19, 2011·European Journal of Clinical Investigation·Pavol PapayWalter Reinisch
Mar 30, 2011·PLoS Medicine·Alice ZwerlingMadhukar Pai
Nov 29, 2011·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·D B Banach, T G Harris
Nov 28, 2012·Journal of Immigrant and Minority Health·Terri SimpsonCynthia Jobb
Feb 15, 2014·Statistical Methods in Medical Research·Jonathan W BartlettUNKNOWN Alzheimer's Disease Neuroimaging Initiative*
May 16, 2014·Journal of Clinical Microbiology·Marc TebrueggeSaul N Faust
Jun 11, 2014·Nature Reviews. Rheumatology·Helen L WrightSteven W Edwards
Apr 9, 2015·Molecular Diagnosis & Therapy·Jonathon R CampbellFawziah Marra
Mar 25, 2016·MMWR. Morbidity and Mortality Weekly Report·Jorge L SalinasAdam J Langer
Dec 22, 2016·Journal of Clinical Medicine·Odile WéraCécile Oury
Jan 6, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David M LewinsohnGail L Woods

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Citations

Nov 2, 2019·The American Journal of Tropical Medicine and Hygiene·Mao-Shui Wang, Xin-Jie Liu
Jun 3, 2020·Inflammatory Bowel Diseases·Jana G HashashMiguel D Regueiro
Jun 16, 2021·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Oh Joo KweonMi-Kyung Lee

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