Risk factors for infection with carbapenem-resistant Klebsiella pneumoniae after liver transplantation: the importance of pre- and posttransplant colonization

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
M GiannellaP Viale

Abstract

Improved understanding of risk factors associated with carbapenem-resistant-Klebsiella pneumoniae (CR-KP) infection after liver transplantation (LT) can aid development of effective preventive strategies. We performed a prospective cohort study of all adult patients undergoing LT at our hospital during 30-month period to define risk factors associated with CR-KP infection. All patients were screened for CR-KP carriage by rectal swabs before and after LT. No therapy was administered to decolonize or treat asymptomatic CR-KP carriers. All patients were monitored up to 180 days after LT. Of 237 transplant patients screened, 41 were identified as CR-KP carriers (11 at LT, 30 after LT), and 20 developed CR-KP infection (18 bloodstream-infection, 2 pneumonia) a median of 41.5 days after LT. CR-KP infection rates among patients non-colonized, colonized at LT, and colonized after LT were 2%, 18.2% and 46.7% (p < 0.001). Independent risk factors for CR-KP infection identified by multivariate analysis, included: renal-replacement-therapy; mechanical ventilation > 48 h; HCV recurrence, and colonization at any time with CR-KP. Based on these four variables, we developed a risk score that effectively discriminated patients at low versus hig...Continue Reading

References

Jun 1, 1988·American Journal of Infection Control·J S GarnerJ M Hughes
Sep 23, 2008·American Journal of Surgery·Zaccaria RicciClaudio Ronco
Nov 1, 2008·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Gopi PatelDavid P Calfee
Apr 2, 2010·Diagnostic Microbiology and Infectious Disease·May NguyenChristine J Kubin
Sep 30, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Emmanuel WeissCatherine Paugam-Burtz
Aug 11, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G GernaE Arbustini
Nov 19, 2011·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M D BergamascoC S Abboud
Apr 3, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jayant S KalpoeShirish Huprikar
Apr 18, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M AkovaY Carmeli
Jul 4, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mario TumbarelloMatteo Bassetti
Dec 25, 2012·Journal of Hepatology·Marina Berenguer, Detlef Schuppan
Jan 31, 2013·Intensive Care Medicine·R P DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
Feb 16, 2013·Expert Review of Anti-infective Therapy·Nicola PetrosilloPierluigi Viale
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D van DuinUNKNOWN AST Infectious Diseases Community of Practice
Aug 24, 2013·The Lancet Infectious Diseases·L Silvia Munoz-PriceJohn P Quinn
Sep 10, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C J ClancyM Hong Nguyen
Oct 1, 2013·Expert Review of Anti-infective Therapy·Pierluigi VialeMario Tumbarello
Jan 28, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael J SatlinThomas J Walsh
Mar 19, 2014·The Journal of Infectious Diseases·Elizabeth Diago-NavarroBettina C Fries
Mar 29, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Maddalena GiannellaPierluigi Viale
Apr 16, 2014·Antimicrobial Agents and Chemotherapy·Mario TumbarelloPierluigi Viale
Jul 2, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M GiannellaM Tumbarello

❮ Previous
Next ❯

Citations

Jan 15, 2016·Virulence·Antonios Kritikos, Oriol Manuel
Jul 3, 2016·Interactive Cardiovascular and Thoracic Surgery·Antonio SalsanoFrancesco Santini
May 27, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jonathan Hand, Gopi Patel
Jan 26, 2017·The British Journal of Surgery·V R BertuzzoM Cescon
May 26, 2017·Current Opinion in Infectious Diseases·Elizabeth RobilottiStan Deresinski
Jul 28, 2017·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Pin LiuJingfu Qiu
Jan 24, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Cristiana LaiciStefano Faenza
Aug 11, 2017·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Giovanni VarottiIris Fontana
May 29, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Michele BartolettiMaddalena Giannella
May 3, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nenad MacesicAnne-Catrin Uhlemann
Nov 21, 2018·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Fatma ErdemZerrin Aktas
Mar 17, 2019·Expert Review of Anti-infective Therapy·Maddalena GiannellaPierluigi Viale
Mar 28, 2019·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Katherine E GoodmanUNKNOWN CDC Prevention Epicenters Program
Dec 3, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D R GiacobbeUNKNOWN ISGRI-SITA (Italian Study Group on Resistant Infections of the Società Italiana Terapia Antinfettiva)
May 26, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Jacques SimkinsLilian M Abbo
Jan 27, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Maristela P FreireLigia C Pierrotti
May 12, 2019·Clinical Transplantation·Lilian M AbboUNKNOWN AST ID Community of Practice
Mar 10, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Judith A AnesiJennifer H Han
May 22, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Alessandra MularoniBruno Gridelli
Mar 13, 2018·World Journal of Hepatology·Alberto FerrareseMarco Senzolo
Dec 29, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Maria Carmen FariñasUNKNOWN ENTHERE Study Group, the Group for Study of Infection in Transplantation of the Spanish Society of Infectious Diseases and C
Feb 4, 2021·The Journal of Antimicrobial Chemotherapy·Maddalena GiannellaElda Righi
May 11, 2018·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Ajeet SinghArvinder Singh Soin
May 11, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M Hong NguyenCornelius J Clancy
Aug 16, 2017·Transplantation Reviews·J M AguadoUNKNOWN Spanish Network for Research in Infectious Diseases (REIPI) (RD16/0016)

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Related Papers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Jayant S KalpoeShirish Huprikar
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Joy VargheseMohamed Rela
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
M GiannellaP Viale
Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
M GiannellaM Tumbarello
© 2022 Meta ULC. All rights reserved