Risk Factors for Insulin Resistance, Metabolic Syndrome, and Diabetes in 248 HFE C282Y Homozygotes Identified by Population Screening in the HEIRS Study

Metabolic Syndrome and Related Disorders
James C BartonRonald T Acton

Abstract

We sought to identify risk factors for insulin resistance, metabolic syndrome (MetS), and diabetes mellitus in 248 non-Hispanic white HFE C282Y homozygotes identified by population screening. We analyzed observations obtained prospectively in a postscreening examination: age; sex; body mass index (BMI); systolic/diastolic blood pressure; metacarpophalangeal (MP) joint hypertrophy; hepatomegaly; complete blood counts; alanine/aspartate aminotransferase levels; elevated C-reactive protein (>0.5 mg/dL); transferrin saturation; serum ferritin; homeostasis model assessment-insulin resistance (HOMA-IR); and MetS. Twenty-six participants (10.5%) had diabetes diagnoses. A significant trend across HOMA-IR quartiles was observed only for blood neutrophils. Logistic regression on HOMA-IR fourth quartile revealed positive associations: age (P = 0.0002); male sex (P = 0.0022); and BMI (P < 0.0001). HOMA-IR fourth quartile predicted MetS (P < 0.0001). Logistic regression on diabetes revealed positive associations: age (P = 0.0012); male sex (P = 0.0068); MP joint hypertrophy (P = 0.0167); neutrophils (P = 0.0342); and MetS (P = 0.0298). Serum ferritin did not predict HOMA-IR fourth quartile, MetS, or diabetes. In screening C282Y homozygotes,...Continue Reading

References

Jan 1, 1978·CRC Critical Reviews in Clinical Laboratory Sciences·C P Alfrey
Aug 1, 1977·Journal of the American Geriatrics Society·G KimmerlingG M Reaven
Jun 1, 1992·Gastroenterology·M J MüllerF W Schmidt
Feb 1, 1986·The Journal of Clinical Endocrinology and Metabolism·P Lönnroth, U Smith
May 30, 1974·The New England Journal of Medicine·D A LipschitzC A Finch
Jan 1, 1968·The American Journal of the Medical Sciences·S P BalcerzakM P Westerman
Jun 1, 1983·The Journal of Clinical Investigation·J W RoweJ S Flier
Jan 1, 1980·American Journal of Hematology·Y MatznerC Hershko
Jan 1, 1981·Metabolism: Clinical and Experimental·G PaganoG Lenti
Sep 2, 1999·The New England Journal of Medicine·J K OlynykL W Powell
May 16, 2000·The Journal of Laboratory and Clinical Medicine·P NielsenJ Düllmann
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Jul 20, 2001·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·H E Lebovitz
Sep 13, 2002·Journal of the American College of Cardiology·Fahim AbbasiGerald M Reaven
Dec 31, 2002·JAMA : the Journal of the American Medical Association·Ali H MokdadJames S Marks
Feb 18, 2003·The American Journal of the Medical Sciences·Christine E McLarenUNKNOWN Hemochromatosis and Iron Overload Study Research Investigators
Jun 1, 1956·The Journal of Clinical Investigation·K R REISSMANN, M R DIETRICH
Sep 29, 2004·Diabetes Care·Megan JehnEliseo Guallar
Nov 13, 2004·Metabolism: Clinical and Experimental·Daniel A Garca-EstévezJosé Cabezas-Cerrato
Apr 29, 2005·The New England Journal of Medicine·Paul C AdamsUNKNOWN Hemochromatosis and Iron Overload Screening (HEIRS) Study Research Investigators
Jul 27, 2005·Diabetes Care·Claudia BozziniRoberto Corrocher
Sep 27, 2005·Lancet·K George M M AlbertiUNKNOWN IDF Epidemiology Task Force Consensus Group
Apr 6, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Leon A AdamsDavid Brandhagen
Jun 27, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Paul C AdamsUNKNOWN Hemochromatosis and Iron Overload Screening Study Research Investigators
Feb 14, 2008·Diabetes, Obesity & Metabolism·C M AlexanderS M Grundy
Jun 21, 2008·Diabetes Research and Clinical Practice·E P O'SullivanC H Walsh
Nov 20, 2008·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Gordon D McLarenUNKNOWN Hemochromatosis and Iron Overload Screen (HEIRS) Study Research Investigators
Jun 12, 2009·Gender Medicine·Eliza B Geer, Wei Shen

❮ Previous
Next ❯

Citations

Mar 24, 2017·Journal of Diabetes Research·James C Barton, Ronald T Acton

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Software Mentioned

GB
Stat
Excel

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.