Risk factors for intensive care unit-acquired weakness: A systematic review and meta-analysis

Acta Neurologica Scandinavica
Tao YangXiuming Xi

Abstract

Intensive care unit-acquired weakness (ICUAW) occurs frequently in the context of critical illness without alternative plausible cause and specific treatment options, and it is important to identify and summarize the independent risk factors for ICUAW. PubMed, Embase, Central, China Biological Medicine, China National Knowledge Infrastructure, VIP and Wanfang databases were searched from database inception until 10 July 2017. Prospective cohort studies on adult ICU patients who were diagnosed with ICUAW using either clinical or electrophysiological criteria were selected. Meta-analysis was performed using Stata version 12.0. The results were analysed using odds ratios (OR) and 95% confidence intervals (CI). Data were pooled using a random-effects model, and heterogeneity was assessed using the I2 statistic. Qualitative analysis and systematic review were used for risk factors that were deemed inappropriate to combine. Fourteen prospective cohort studies were included in this review. The meta-analysis showed that Acute Physiology and Chronic Health Evaluation II score (OR, 1.05; 95%CI, 1.01-1.10), neuromuscular blocking agents (OR, 2.03; 95%CI, 1.22-3.40) and aminoglycosides (OR, 2.27; 95%CI, 1.07-4.81) were found to be signific...Continue Reading

Associated Clinical Trials

References

Jun 13, 2000·JPEN. Journal of Parenteral and Enteral Nutrition·G MinardE A Tolley
Aug 21, 2001·Intensive Care Medicine·J Garnacho-MonteroM R Moyano-Del-Estad
Jan 22, 2002·Critical Care Medicine·P E Marik, G P Zaloga
Dec 11, 2002·JAMA : the Journal of the American Medical Association·Bernard De JongheUNKNOWN Groupe de Réflexion et d'Etude des Neuromyopathies en Réanimation
Feb 10, 2004·Intensive Care Medicine·Bernard De JongheLaurent Brochard
Jun 5, 2004·The Journal of Trauma·Amanda M LairdMichael C Chang
Mar 26, 2005·Journal of Neurology·J BednaríkI Cundrle
Feb 10, 2006·Intensive Care Medicine·M EikermannJ Peters
Apr 21, 2006·The New England Journal of Medicine·Kenneth P SteinbergUNKNOWN National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network
Oct 3, 2006·Critical Care Medicine·Dries TestelmansGhislaine Gayan-Ramirez
Dec 2, 2006·American Journal of Respiratory and Critical Care Medicine·Greet HermansGreet Van den Berghe
Jul 20, 2007·Intensive Care Medicine·Robert D StevensDale M Needham
Mar 26, 2009·The New England Journal of Medicine·Simon FinferJuan J Ronco
May 9, 2009·The Journal of Clinical Investigation·Kevin R NovakMark M Rich
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Feb 6, 2010·Critical Care Medicine·Robert D StevensTarek Sharshar
Feb 6, 2010·Critical Care Medicine·Nicola LatronicoBruno Guarneri
Apr 1, 2010·BMC Medicine·Susan MallettDouglas G Altman
Jun 23, 2010·Critical Care : the Official Journal of the Critical Care Forum·Steffen Weber-CarstensDidier Keh
Jul 3, 2010·Critical Care : the Official Journal of the Critical Care Forum·Greet HermansGhislaine Gayan-Ramirez
Sep 4, 2010·American Journal of Respiratory and Critical Care Medicine·Samir JaberStefan Matecki
Sep 17, 2010·The New England Journal of Medicine·Laurent PapazianUNKNOWN ACURASYS Study Investigators
Jul 1, 2011·The New England Journal of Medicine·Michael P CasaerGreet Van den Berghe
Dec 15, 2012·Journal of Cellular Biochemistry·Zaira AversaPer-Olof Hasselgren
Mar 19, 2013·Critical Care : the Official Journal of the Critical Care Forum·Waleed AlhazzaniMaureen O Meade
Jun 19, 2013·The International Journal of Biochemistry & Cell Biology·Bradley S GordonScot R Kimball
Oct 11, 2013·JAMA : the Journal of the American Medical Association·Zudin A PuthuchearyHugh E Montgomery
May 16, 2014·American Journal of Respiratory and Critical Care Medicine·Greet HermansGreet Van den Berghe
Aug 16, 2015·Journal of the Neurological Sciences·Luan Nguyen The, Cong Nguyen Huu
Apr 16, 2016·Journal of Intensive Care Medicine·Oscar PeñuelasAndrés Esteban

❮ Previous
Next ❯

Citations

Feb 23, 2020·Intensive Care Medicine·Ilse VanhorebeekGreet Van den Berghe
Aug 3, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Jennifer R A Jones, David M Griffith
Sep 8, 2020·Journal of Cachexia, Sarcopenia and Muscle·Joerg C SchefoldSteffen Weber-Carstens
May 3, 2020·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Werner J Z'Graggen, Hatice Tankisi
Aug 20, 2020·Acta Anaesthesiologica Scandinavica·Ólöf R ÁmundadóttirGísli H Sigurðsson
Dec 2, 2020·International Journal of Environmental Research and Public Health·Lucía Sagarra-Romero, Andrea Viñas-Barros
Dec 15, 2020·Current Opinion in Anaesthesiology·Johannes Kalbhenn
Nov 21, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Cristina DaiaGelu Onose
Oct 28, 2020·International Journal of Molecular Sciences·Heta LadPenney M Gilbert
Dec 19, 2020·Journal of Nursing Measurement·Roberto Miguel Gonçalves MendesAlexandre José Oliveira Gomes
Apr 21, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Robert FrithiofAnna Rostedt Punga
Mar 19, 2021·Journal of Applied Physiology·Kevin CheungMatti D Allen
Oct 2, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Sergio BagnatoFrancesca Rubino
May 28, 2021·Brain Pathology·Gayathri Narayanappa, Bevinahalli Nanjegowda Nandeesh
May 8, 2020·The Journal of Medical Investigation : JMI·Nobuto NakanishiJun Oto
Oct 8, 2021·Continuum : Lifelong Learning in Neurology·Torrey Boland Birch
Dec 4, 2021·Intensive Care Medicine Experimental·Paula Martín-VicenteLaura Amado-Rodríguez
Jan 9, 2022·Journal of Cachexia, Sarcopenia and Muscle·Madu N SoaresRob C I Wüst

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.