Abstract
Periventricular leukomalacia, a major cause of neurologic disabilities in preterm infants, can be isolated or associated with intraventricular and periventricular hemorrhage. To determine the risk factors for isolated periventricular leukomalacia, we retrospectively studied the characteristics of all very low birth weight infants affected by isolated periventricular leukomalacia who were delivered over a 5-year period and compared them with a control group of very low birth weight infants, matched within 2 weeks for gestational age, with no central nervous system pathology, and born during the same period. In total, 20 affected infants were compared with 98 control infants. Neonatal sepsis caused by coagulase-negative Staphylococcus (P = 0.014) and neonatal seizure (P = 0.026) were associated with isolated periventricular leukomalacia only on univariate analysis. Three variables demonstrated statistically significant associations with isolated periventricular leukomalacia on both univariate and multivariate logistic regression analysis as independent risk factors: birth weight (odds ratio, 4.31; 95% confidence interval, 1.54-12.06; P = 0.005), early neonatal hypotension requiring combined inotropic therapy (odds ratio, 4.90; 95...Continue Reading
References
Jul 31, 1992·Behavioural Brain Research·L S de VriesL M Dubowitz
May 29, 2001·Neurology·H KadhimG Sébire
Oct 20, 2001·Pediatric Research·J J Volpe
Aug 1, 2002·Pediatric Research·Terrie InderChristine Winterbourn
Sep 19, 2003·Journal of Perinatology : Official Journal of the California Perinatal Association·Judith S MercerWilliam Oh
Dec 4, 2003·Early Human Development·S E MartensUNKNOWN Leiden Follow-Up Project on Prematurity, The Netherlands
Mar 26, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Toby Debra YanowitzBeverly Sobchak Brozanski
May 7, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Reese ClarkDaniel K Benjamin
Dec 3, 2004·Pediatrics·Michael J MunroCharles P Barfield
Jan 1, 2005·Brain & Development·Yasutaka MurataShigehiko Mizutani
Mar 3, 2005·Pediatrics·Susan R HintzUNKNOWN NICHD Neonatal Research Network
Apr 30, 2005·Acta Paediatrica·M Murase, A Ishida
Jun 16, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·K J RademakerL S de Vries
Jan 20, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·S HosonoK Harada
Jan 31, 2007·Stroke; a Journal of Cerebral Circulation·Stephen A BackMelissa M McClure
Aug 3, 2007·Interactive Cardiovascular and Thoracic Surgery·B KorbmacherE Gams
Jan 2, 2008·Pediatrics·Petra M A LemmersFrank van Bel
Jun 7, 2008·The Journal of Pediatrics·Divyen K ShahTerrie E Inder
Jun 12, 2008·Neuroradiology·Lara M LeijserGerda van Wezel-Meijler
Oct 10, 2008·American Journal of Perinatology·Jing LiuQi Wang
Oct 14, 2008·American Journal of Perinatology·Sheri L NemerofskyJohn M Lorenz
Oct 28, 2008·Acta Obstetricia Et Gynecologica Scandinavica·Eleftheria HatzidakiChristina Giannakopoulou
Nov 26, 2008·The Journal of Pediatrics·Beau BattonMichele Walsh
Dec 5, 2008·Neonatology·Jacob KuintAyala Maayan-Metzger
May 1, 2009·Pediatrics·Adelina PellicerFernando Cabañas
Sep 11, 2009·Annals of Neurology·Linda S de Vries
Oct 22, 2009·Archives of Disease in Childhood. Fetal and Neonatal Edition·S HorschM Blennow
Jan 29, 2011·Journal of Perinatology : Official Journal of the California Perinatal Association·J W LoganUNKNOWN ELGAN Study Investigators
Citations
Jul 19, 2013·Pediatric Neurology·J Wells LoganUNKNOWN ELGAN Study investigators
Oct 18, 2015·Pediatric Neurology·Muhammad T Al Rifai, Khalil I Al Tawil
May 29, 2014·Journal of Neuroscience Research·Mari IchinoseTomoyuki Fujii
Oct 1, 2014·Acta Paediatrica·Vibeke R EriksenGorm Greisen
Sep 17, 2013·Orvosi hetilap·György Balla, Miklós Szabó
Jun 25, 2015·CoDAS·Dionísia Aparecida Cusin LamônicaJamile Lozano Biazon
Sep 21, 2017·PloS One·Jichong HuangDezhi Mu
Feb 1, 2017·PloS One·Vibeke Ramsgaard EriksenGorm Greisen
Dec 16, 2018·Journal of Perinatology : Official Journal of the California Perinatal Association·Satvinder GhotraNaeem Khan
Mar 19, 2014·Pediatrics·Dany E WeiszPrakesh S Shah