Risk factors for isolated periventricular leukomalacia

Pediatric Neurology
Khalil I Al TawilSaif A Al Saif

Abstract

Periventricular leukomalacia, a major cause of neurologic disabilities in preterm infants, can be isolated or associated with intraventricular and periventricular hemorrhage. To determine the risk factors for isolated periventricular leukomalacia, we retrospectively studied the characteristics of all very low birth weight infants affected by isolated periventricular leukomalacia who were delivered over a 5-year period and compared them with a control group of very low birth weight infants, matched within 2 weeks for gestational age, with no central nervous system pathology, and born during the same period. In total, 20 affected infants were compared with 98 control infants. Neonatal sepsis caused by coagulase-negative Staphylococcus (P = 0.014) and neonatal seizure (P = 0.026) were associated with isolated periventricular leukomalacia only on univariate analysis. Three variables demonstrated statistically significant associations with isolated periventricular leukomalacia on both univariate and multivariate logistic regression analysis as independent risk factors: birth weight (odds ratio, 4.31; 95% confidence interval, 1.54-12.06; P = 0.005), early neonatal hypotension requiring combined inotropic therapy (odds ratio, 4.90; 95...Continue Reading

References

Jul 31, 1992·Behavioural Brain Research·L S de VriesL M Dubowitz
Sep 19, 2003·Journal of Perinatology : Official Journal of the California Perinatal Association·Judith S MercerWilliam Oh
Dec 4, 2003·Early Human Development·S E MartensUNKNOWN Leiden Follow-Up Project on Prematurity, The Netherlands
Mar 26, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Toby Debra YanowitzBeverly Sobchak Brozanski
May 7, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Reese ClarkDaniel K Benjamin
Dec 3, 2004·Pediatrics·Michael J MunroCharles P Barfield
Mar 3, 2005·Pediatrics·Susan R HintzUNKNOWN NICHD Neonatal Research Network
Jun 16, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·K J RademakerL S de Vries
Jan 31, 2007·Stroke; a Journal of Cerebral Circulation·Stephen A BackMelissa M McClure
Aug 3, 2007·Interactive Cardiovascular and Thoracic Surgery·B KorbmacherE Gams
Jun 12, 2008·Neuroradiology·Lara M LeijserGerda van Wezel-Meijler
Oct 10, 2008·American Journal of Perinatology·Jing LiuQi Wang
Oct 14, 2008·American Journal of Perinatology·Sheri L NemerofskyJohn M Lorenz
Oct 28, 2008·Acta Obstetricia Et Gynecologica Scandinavica·Eleftheria HatzidakiChristina Giannakopoulou
Nov 26, 2008·The Journal of Pediatrics·Beau BattonMichele Walsh
Dec 5, 2008·Neonatology·Jacob KuintAyala Maayan-Metzger
Oct 22, 2009·Archives of Disease in Childhood. Fetal and Neonatal Edition·S HorschM Blennow
Jan 29, 2011·Journal of Perinatology : Official Journal of the California Perinatal Association·J W LoganUNKNOWN ELGAN Study Investigators

❮ Previous
Next ❯

Citations

Oct 18, 2015·Pediatric Neurology·Muhammad T Al Rifai, Khalil I Al Tawil
Oct 1, 2014·Acta Paediatrica·Vibeke R EriksenGorm Greisen
Sep 17, 2013·Orvosi hetilap·György Balla, Miklós Szabó
Jun 25, 2015·CoDAS·Dionísia Aparecida Cusin LamônicaJamile Lozano Biazon
Dec 16, 2018·Journal of Perinatology : Official Journal of the California Perinatal Association·Satvinder GhotraNaeem Khan
Mar 19, 2014·Pediatrics·Dany E WeiszPrakesh S Shah

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.