Risk Factors for Local and Distant Recurrence After Surgical Treatment in Patients With Non-Small-Cell Lung Cancer

Clinical Lung Cancer
Dariusz Adam DziedzicPolish Lung Cancer Study Group (PLCSG)

Abstract

The purpose of this study was to identify independent perioperative and pathologic variables associated with non-small-cell lung cancer (NSCLC) recurrence after complete surgical resection. A retrospective examination was performed of a prospectively maintained database of patients who underwent resection for NSCLC from January 2009 to January 2014 at a multi-institution. Clinicopathologic variables were evaluated for their influence on frequency of recurrence. Cox proportional regression hazard model analysis examined the association of recurrence in NSCLC. Of these patients, 2816 (19.3%) experienced recurrence of primary cancer. Local or distant recurrence was found in 20.5% and 79.5% of patients, respectively. Median follow-up was 27.9 months (range, 11.4-66.0 months). The analysis indicated independent effects of the following risk factors on the risk of recurrence: age 64-90 years (hazard ratio [HR], 1.136; 95% confidence interval [CI] 1.024-1.261), histologic type adenocarcinoma (HR, 1.117; 95% CI 1.005-1.24), blood vessel invasion (HR, 1.236; 95% CI, 1.124-1.359), lymphatic vessel invasion (HR, 1.287; 95% CI, 1.176-1.409), visceral pleural invasion (HR, 1.641; 95% CI, 1.215-2.218), N1 disease (HR, 1.142; 95% CI, 0.99-1.3...Continue Reading

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Citations

Apr 7, 2018·Archives of Pathology & Laboratory Medicine·Nasser K Altorki
Jul 4, 2018·Nature Reviews. Clinical Oncology·Christopher AbboshCharles Swanton
Mar 15, 2019·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Dugald SeelyAndrew Seely
Jul 31, 2019·American Journal of Physical Medicine & Rehabilitation·Duc HaJames D Murphy
Apr 10, 2018·Cancer Biomarkers : Section a of Disease Markers·Tao GuoChundong Gu
Jun 9, 2020·Cancer Biomarkers : Section a of Disease Markers·Yongjian ZhangKoujun Zhu
Aug 4, 2019·Medical Oncology·Daniela ZaniniMaria Rosa Chitolina Schetinger
Dec 2, 2020·Journal of Clinical Medicine·Bo Gun KhoIn-Jae Oh

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