Risk factors for metabolic syndrome after liver transplantation: A systematic review and meta-analysis

Transplantation Reviews
Line Buch ThoefnerAllan Rasmussen

Abstract

Metabolic syndrome is associated with increased risk of cardiovascular events, which contributes to the elevated mortality rate among liver transplant recipients. The objective of this systematic review and meta-analysis was to assess the prevalence and risk factors for metabolic syndrome after liver transplantation. The databases Medline and Scopus were searched for observational studies evaluating prevalence and risk factors for metabolic syndrome after liver transplantation. Meta-analyses were performed based on odds ratios (ORs) from multivariable analyses. The Newcastle-Ottawa Scale was used for assessment of bias. The literature search generated 1815 records of which 16 articles were included comprising 3539 patients. The post-transplant prevalence of metabolic syndrome was 39%. Eight studies were eligible for meta-analyses, which showed that pre-transplant diabetes (OR=3.54, 95% confidence interval (CI): 2.51-4.98) and pre-transplant obesity (OR=2.44, 95% CI: 1.48-4.03) were risk factors for metabolic syndrome. Six out of seven studies reported that recipients with metabolic syndrome had a higher incidence of cardiovascular events. Four studies showed that survival was not affected by metabolic syndrome. The prevalences ...Continue Reading

References

Jul 3, 1998·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J E EverhartJ H Hoofnagle
Jan 15, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·H Cortez-PintoM C De Moura
Jun 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D L BigamM S Cattral
Sep 27, 2000·Journal of Endocrinological Investigation·P Marchetti, R Navalesi
Jul 19, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·M CharltonK P Batts
Sep 12, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J PruthiT L Fong
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gianfranco PaganoMario Rizzetto
Dec 4, 2002·JAMA : the Journal of the American Medical Association·Hanna-Maaria LakkaJukka T Salonen
Apr 2, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giulio MarchesiniMario Rizzetto
Sep 27, 2005·Lancet·K George M M AlbertiUNKNOWN IDF Epidemiology Task Force Consensus Group
Mar 7, 2006·Lipids in Health and Disease·Jingting JiangNing Xu
May 12, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Y FutagawaD W Gjertson
Aug 1, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marie LaryeaKevork M Peltekian
Feb 26, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J LeonardM Charlton
May 1, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Muhammad Y SheikhArun J Sanyal
Nov 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Giampaolo BianchiMarco Zoli
Nov 26, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Shahid M MalikJawad Ahmad
Feb 23, 2010·International Journal of Surgery·David MoherUNKNOWN PRISMA Group
Mar 23, 2010·Transplantation Proceedings·M L Ruiz-RebolloA Caro-Patón
May 22, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K D S WattM R Charlton
Sep 25, 2010·Journal of the American College of Cardiology·Salvatore MottilloMark J Eisenberg
Jan 22, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ido LaishZiv Ben Ari
Jul 16, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kymberly D Watt
Nov 24, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M AshwellS Gibson
Dec 6, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mazen AlbeldawiNizar N Zein
Mar 14, 2012·Transplantation·Belinda Martínez-SaldivarAntoni Rimola
Jul 24, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Surabhi MadhwalMarco A Costa
Nov 7, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Martin F SprinzlMarcus Schuchmann
Jan 8, 2013·Metabolic Syndrome and Related Disorders·Valter SilvaAntonio José Grande
May 11, 2013·Nigerian Medical Journal : Journal of the Nigeria Medical Association·Jyoti Prakash PhukanJatindra Prasad Deka
Jul 3, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Maria Elena LunatiEmanuela Orsi
Jul 31, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Eric R KallwitzScott J Cotler
Oct 22, 2013·Annals of Transplantation : Quarterly of the Polish Transplantation Society·Orit UzielZiv Ben-Ari
Feb 13, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Lucilene R AnastácioEduardo G Vilela
Oct 1, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fredrik ÅbergHelena Isoniemi

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Citations

Jan 30, 2020·Circulation·Salim S ViraniUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Sep 26, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Norihisa Shigemura, Yoshiya Toyoda
Apr 11, 2020·European Heart Journal. Quality of Care & Clinical Outcomes·Abraham Sonny
Jun 2, 2020·World Journal of Gastroenterology : WJG·Chiara BecchettiJean-François Dufour
Aug 11, 2020·World Journal of Gastroenterology : WJG·Tian ShenXiao Xu
Jul 10, 2019·Frontiers in Neuroscience·Anne-Loes OpperhuizenAndries Kalsbeek
Jun 2, 2020·World Journal of Gastroenterology : WJG·Hai-Tao HuangShu-Sen Zheng
Sep 14, 2019·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Εvangelos CholongitasIoannis Goulis
Oct 27, 2020·Metabolic Syndrome and Related Disorders·Stefano GittoUNKNOWN MEDITRA Research Group
Nov 29, 2020·Endocrine Reviews·Mamatha BhatMinna Woo
Sep 29, 2019·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Takeo ToshimaMasaki Mori
Jan 28, 2021·Circulation·Salim S ViraniUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Apr 23, 2020·European Journal of Gastroenterology & Hepatology·Javier Tejedor-TejadaGloria Sánchez-Antolín
Apr 4, 2021·Journal of Clinical Medicine·Yip Han ChinMark Dhinesh Muthiah
Jun 25, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Amirhossein AzhieMamatha Bhat
Aug 28, 2021·Nutrients·Maria TessitoreClaudia Mandato
Oct 2, 2021·Immunity, Inflammation and Disease·Kinga CzarneckaMagdalena Durlik
Nov 11, 2021·Clinical Transplantation·Chiara BecchettiGiacomo Germani

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