Risk Factors for Mortality and Respiratory Support in Elderly Patients Hospitalized with COVID-19 in Korea

Journal of Korean Medical Science
Ji Yeon LeeHyun Ha Chang

Abstract

The mortality risk of coronavirus disease 2019 (COVID-19) is higher in patients with older age, and many elderly patients are reported to require advanced respiratory support. We reviewed medical records of 98 patients aged ≥ 65 years who were hospitalized with COVID-19 during a regional outbreak in Daegu/Gyeongsangbuk-do province of Korea. The outcome measures were in-hospital mortality and the treatment with mechanical ventilation (MV) or high-flow nasal cannula (HFNC). The median age of the patients was 72 years; 55.1% were female. Most (74.5%) had at least one underlying condition. Overall case fatality rate (CFR) was 20.4%, and median time to death after admission was 8 days. The CFR was 6.1% among patients aged 65-69 years, 22.7% among those aged 70-79 years, and 38.1% among those aged ≥ 80 years. The CFR among patients who required MV was 43.8%, and the proportion of patients received MV/HFNC was 28.6%. Nosocomial acquisition, diabetes, chronic lung diseases, and chronic neurologic diseases were significant risk factors for both death and MV/HFNC. Hypotension, hypoxia, and altered mental status on admission were also associated with poor outcome. CRP > 8.0 mg/dL was strongly associated with MV/HFNC (odds ratio, 26.31; 95...Continue Reading

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Citations

Aug 1, 2020·Expert Review of Respiratory Medicine·Syed Shahzad HasanSyed Tabish Razi Zaidi
Sep 13, 2020·Journal of Community Health·Farha Musharrat Noor, Md Momin Islam
Oct 10, 2020·Aging Clinical and Experimental Research·Guerino RecinellaMarco Zoli
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Jan 4, 2021·International Urology and Nephrology·Ruyi CaiQiang He
Dec 10, 2020·Journal of Clinical Medicine·Jihye HwangHyon-Ah Yi
Nov 4, 2020·Journal of Korean Medical Science·Nayoung RyooSangYun Kim
Nov 25, 2020·Journal of Korean Medical Science·KyungHee KimKwang Sung Min
Mar 9, 2021·Journal of Healthcare Informatics Research·Yijun ShaoQing Zeng-Treitler
Mar 2, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Kyeong Hyang ByeonKyu Dong Cho
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