Abstract
Multifocal and diffuse hepatic hemangiomas are true infantile hemangiomas, which likely exist in a continuum. We reviewed our hepatic hemangioma registry to identify prognostic indicators for mortality. Registry records entered between 1995 and 2012 were reviewed. Clinical characteristics were evaluated for prognostic significance using the multivariable Cox proportional hazards model. Survival data were analyzed using the Kaplan-Meier product-limit method. We identified 123 patients with multifocal (n=91) and diffuse (n=32) hepatic hemangiomas. Mortality was 16% (n=20); 40% (n=8) had multifocal and 60% (n=12) had diffuse lesions. A diagnosis of diffuse disease (hazard ratio: 9.9, 95% CI: 2.0-50.8, P=.002) and congestive heart failure (CHF) (hazard ratio: 3.9, 95% CI: 1.3-14.2, P=.031) were significant risk factors for mortality across the continuum; age at presentation, cardiomegaly, presence of shunts, and hypothyroidism were not statistically significant independent risk factors. Among patients with diffuse lesions, eight (67%) who died had abdominal compartment syndrome, which was also associated with mortality (P=.002). Hepatic hemangioma patients with CHF or diffuse disease are at higher risk for mortality. Patients with ...Continue Reading
References
Nov 1, 1978·The Journal of Dermatologic Surgery and Oncology·B Berman, H Lim
Jan 1, 1986·Journal of Pediatric Surgery·R C Cohen, N A Myers
Jul 1, 1995·Journal of Internal Medicine·B MyrupJ Faber
Jan 1, 1995·Journal of Pediatric Surgery·M DavenportE R Howard
Sep 1, 1996·The Journal of Pediatrics·L M BoonJ B Mulliken
Feb 18, 1999·Journal of Pediatric Surgery·J A DallerJ Reyes
Jul 20, 2000·The New England Journal of Medicine·S A HuangP R Larsen
Feb 28, 2002·Radiology·Ara KassarjianPatricia E Burrows
Aug 2, 2003·Journal of Pediatric Surgery·S WarmannJ Fuchs
Dec 5, 2003·Pediatrics·Daniel KonradKusiel Perlman
Feb 21, 2004·AJR. American Journal of Roentgenology·Ara KassarjianPatricia E Burrows
Mar 24, 2004·Clinical Radiology·J A HughesR De Bruyn
Jan 9, 2007·Journal of Pediatric Surgery·Emily R Christison-LagaySteven J Fishman
Aug 24, 2007·Surgical Oncology·Rebecka L Meyers
Jan 22, 2008·Journal of Pediatric Surgery·Haley DraperAnnie Fecteau
Nov 11, 2008·Pediatric Transplantation·Malgorzata Markiewicz-KijewskaPiotr Kalicinski
Nov 11, 2008·Pediatric Transplantation·Enke GrabhornRainer Ganschow
Jan 23, 2009·Journal of Pediatric Surgery·Belinda DickieRichard G Azizkhan
Jul 10, 2009·Pediatric Radiology·Wendy ZenzenAhmad I Alomari
May 22, 2010·The Journal of Pediatrics·Juliette Mazereeuw-HautierChristine Bodemer
Apr 27, 2011·Pediatric Dermatology·Kimberly A HoriiUNKNOWN Hemangioma Investigator Group
Apr 27, 2011·Pediatric Dermatology·Iwei YehIlona J Frieden
Oct 15, 2011·Pediatric Dermatology·Janie BertrandJulie Powell
Jan 17, 2012·Journal of Pediatric Surgery·Ann M KulungowskiSteven J Fishman
Citations
Aug 18, 2016·Scientific Reports·Yi JiLi Yang
Oct 1, 2016·Journal of Pediatric Surgery·Kai LiXianmin Xiao
Jan 6, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giulia VarrassoAnna Clerico
Jul 21, 2017·Pediatric Blood & Cancer·Denise M AdamsCameron C Trenor
Jul 22, 2017·Pediatric Dermatology·Donald WarrenMoise Levy
Sep 10, 2016·World Journal of Clinical Pediatrics·Maria GnarraKonstantinos P Economopoulos
Mar 2, 2019·The Journal of Dermatology·Kaiying YangYi Ji
Dec 1, 2017·Neonatal Network : NN·Ashley SartoriSteven Ringer
Mar 18, 2020·AJR. American Journal of Roentgenology·Gary R SchoolerEdward Y Lee
Jul 22, 2020·Current Opinion in Pediatrics·Manuel Valdebran, Lara Wine Lee
Jun 8, 2017·Clinical Case Reports·Faten Al TassehNahida El-Rifai
Jan 11, 2019·Journal of Paediatrics and Child Health·Kaiying YangYi Ji
Nov 14, 2018·European Journal of Pediatrics·Juan-Carlos López-Gutiérrez
Aug 29, 2018·Oxford Medical Case Reports·Alexandra RodriguesFilomena Teixeira
Nov 17, 2020·Frontiers in Pediatrics·Harriet Bagnal HinenLara Wine Lee
Mar 7, 2021·Diagnostics·Bryony LucasIrina Pateva
Oct 19, 2020·Seminars in Pediatric Surgery·Anna McGuireBelinda Hsi Dickie
May 28, 2021·Clinical and Experimental Pediatrics·Hye Lim Jung