Risk Factors for Mortality of Inpatients with Pseudomonas aeruginosa Bacteremia in China: Impact of Resistance Profile in the Mortality

Infection and Drug Resistance
Yulin ZhangBin Cao

Abstract

Pseudomonas aeruginosa bacteremia presents a severe challenge to hospitalized patients. However, to date, the risk factors for mortality among inpatients with P. aeruginosa bacteremia in China remain unclear. This retrospective multicenter study was performed to analyze 215 patients with culture-confirmed P. aeruginosa bacteremia in five healthcare centers in China during the years 2012-2019. Of 215 patients with P. aeruginosa bacteremia, 61 (28.4%) died during the study period. Logistic multivariable analysis revealed that cardiovascular disease (OR=3.978, P=0.001), blood transfusion (OR=5.855, P<0.001) and carbapenem-resistant P. aeruginosa (CRPA) phenotype (OR=4.485, P=0.038) constituted the independent risk factors of mortality. Furthermore, both CRPA and multidrug-resistant P. aeruginosa (MDRPA) phenotypes were found to be significantly associated with 5-day mortality (Log-rank, P<0.05). This study revealed a high mortality rate amongst hospitalized patients with P. aeruginosa bacteremia, and those with cardiovascular diseases, CRPA and MDRPA phenotypes, should be highlighted and given appropriate management in China.

References

Sep 5, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cheol-In KangKang-Won Choe
Mar 29, 2005·Antimicrobial Agents and Chemotherapy·Scott T MicekMarin H Kollef
Dec 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sara E Cosgrove
Jun 26, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H S CheongK R Peck
Oct 4, 2008·Best Practice & Research. Clinical Anaesthesiology·Felix BuddebergDonat R Spahn
Mar 13, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Cristina SuárezJavier Ariza
Jun 30, 2010·Antimicrobial Agents and Chemotherapy·Vincent H TamKevin W Garey
Mar 9, 2011·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Eun-Jeong JooJae-Hoon Song
Jul 29, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A-P MagiorakosD L Monnet
Aug 23, 2011·The American Journal of Emergency Medicine·Ching-Chi LeeMing-Yuan Hong
Dec 14, 2011·Antimicrobial Agents and Chemotherapy·Carmen PeñaUNKNOWN Spanish Network for Research in Infectious Diseases REIPI
Dec 12, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H S M AmmerlaanM J M Bonten
Apr 13, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mical Paul, Leonard Leibovici
Sep 28, 2014·Journal of Medical Microbiology·Raquel Cavalcanti DantasRosineide Marques Ribas
Nov 8, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carmen PeñaUNKNOWN Spanish Network for Research in Infectious Diseases (REIPI)
Feb 13, 2015·Critical Care : the Official Journal of the Critical Care Forum·Teiji SawaJeanine P Wiener-Kronish
May 7, 2015·Critical Care : the Official Journal of the Critical Care Forum·Scott T MicekVandana Menon
Jul 21, 2015·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Chia-Hsin LeeMing-Hsun Lee
Aug 26, 2015·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Antonio OliverCarlos Juan
Jul 29, 2016·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yong ZouJun-Jie Bao
Dec 12, 2018·Infection and Drug Resistance·Taohua LiuQiquan Wan
Nov 27, 2019·International Journal of Antimicrobial Agents·Tanya BabichDafna Yahav
Feb 23, 2020·European Journal of Pediatrics·Benoît PilmisJean-Ralph Zahar

❮ Previous
Next ❯

Software Mentioned

PASW Statistics

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
C SuarezJ Ariza
The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases
Felipe F TuonJaime L Rocha
© 2021 Meta ULC. All rights reserved