Risk factors for multidrug-resistant tuberculosis in urban Pakistan: A multicenter case-control study

International Journal of Mycobacteriology
Ahsan M AhmadNadeem Rizvi

Abstract

To evaluate risk factors for multidrug-resistant tuberculosis (MDR-TB) in an urban setting of Pakistan. In this multicenter case-control study, patients aged 15years old or older with sputum culture and sensitivity (C/S) diagnosed with pulmonary MDR-TB were defined as cases, whereas patients aged 15years old or older with sputum C/S diagnosed and susceptible to pulmonary TB were regarded as controls. Fifty cases and 75 controls were enrolled from three tertiary-care hospitals in Karachi. Multivariable logistic regression models showed that cases were more likely to have had a TB patient in the house prior to the diagnosis of MDR-TB (adjusted odds ratio [ORadj]=3.1, 95% confidence interval [CI]: 1.2, 8.3) or had a history of prior TB treatment (ORadj=4.2, 95% CI: 1.1, 15.4). Furthermore, cases compared with controls tended to be male (ORadj=3.6, 95% CI: 1.4, 9.7), 15-25years of age (ORadj=3.7, 95% CI: 1.2, 11.3), of Sindhi ethnicity (adjusted OR=9.1, 95% CI: 1.9, 43.4) or with low educational attainment (ORadj OR=5.5, 95% CI: 1.7-17.6, for no formal schooling; ORadj=3.8, 95% CI: 1.1-14.1, 1 for 1-5 school years). A TB patient in the house or a history of prior TB treatment was strongly associated with MDR-TB in this study. Furth...Continue Reading

References

Jun 1, 1987·The American Review of Respiratory Disease·I Ben-Dov, G R Mason
Jul 1, 1994·The Journal of Infectious Diseases·S E ValwayS W Dooley
Sep 9, 1993·The New England Journal of Medicine·M D Iseman
Feb 25, 1993·The New England Journal of Medicine·M GobleC R Horsburgh
Apr 1, 1996·Emerging Infectious Diseases·J V RullánF Pozo
Sep 18, 1997·JAMA : the Journal of the American Medical Association·M MooreK G Castro
Feb 20, 1999·American Journal of Epidemiology·J P TaylorL Suarez
Mar 10, 2001·The Journal of Thoracic and Cardiovascular Surgery·B J PomerantzM Pomerantz
Jan 5, 2002·The Korean Journal of Internal Medicine·J H Lee, J H Chang
Apr 4, 2002·The Journal of Infectious Diseases·Christopher DyeBrian G Williams
Oct 3, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·I Suárez-GarcíaA Noguerado-Asensio

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Citations

May 21, 2020·The European Respiratory Journal·C Finn McQuaidRichard G White
Jan 27, 2019·Public Health Nursing·Mei FengJinHong Xu
Jun 15, 2019·International Journal of Preventive Medicine·Parag SharmaAvinash Thakur
Dec 4, 2019·International Journal of Mycobacteriology·Bilal Ahmad RahimiAbdul Wahed Wasiq
Jul 2, 2020·Infection and Drug Resistance·Daniel Biru, Endrias Markos Woldesemayat

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