Risk factors for neonatal sepsis and perinatal death among infants enrolled in the prevention of perinatal sepsis trial, Soweto, South Africa

The Pediatric Infectious Disease Journal
Stephanie SchragPoPS Trial Team

Abstract

Factors associated with neonatal sepsis, an important cause of child mortality, are poorly described in Africa. We characterized factors associated with early-onset (days 0-2 of life) and late-onset (days 3-28) -sepsis and perinatal death among infants enrolled in the Prevention of Perinatal Sepsis Trial (NCT00136370 at ClinicalTrials.gov), Soweto, South Africa. Secondary analysis of 8011 enrolled mothers and their neonates. Prenatal and labor records were abstracted and neonatal wards were monitored for hospitalized Prevention of Perinatal Sepsis-enrolled neonates. Endpoint definitions required clinical and laboratory signs. All univariate factors associated with endpoints at P < 0.15 were evaluated using multivariable logistic regression. About 10.5% (837/8011) of women received intrapartum antibiotic prophylaxis; 3.8% of enrolled versus 15% of hospital births were preterm. Among 8129 infants, 289 had early-onset sepsis, 34 had late-onset sepsis, 49 had culture-confirmed neonatal sepsis and 71 died in the perinatal period. Factors associated with early-onset sepsis included preterm delivery [adjusted relative risk (aRR) = 2.6; 95% confidence interval (CI): 1.4-4.8]; low birth weight (<1500 g: aRR = 6.5, 95% CI: 2.4-17.3); mec...Continue Reading

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Citations

May 6, 2014·Early Human Development·Eileen K Hutton, Julia Thorpe
Jan 7, 2014·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·C L LiuZ Y Sun
Sep 26, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto RomeroTinnakorn Chaiworapongsa
Sep 14, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto RomeroLami Yeo
Feb 21, 2014·Revista Do Instituto De Medicina Tropical De São Paulo·Isabela FurtadoDurval Batista Palhares
Aug 1, 2013·The Pediatric Infectious Disease Journal·Ming-Horng TsaiYhu-Chering Huang
Jul 22, 2017·The Pediatric Infectious Disease Journal·Anna C SealeJames A Berkley
Sep 21, 2019·Journal of Tropical Pediatrics·Pendo P MasanjaMkhoi L Mkhoi
Mar 25, 2019·Global Pediatric Health·Kazi Nazmus SaqeebMohammod Jobayer Chisti
Mar 20, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Shi ChenLu-Quan Li
Jan 24, 2021·Archives of Disease in Childhood·Carolin FleischmannTim Eckmanns
May 28, 2021·International Journal of Antimicrobial Agents·Lison RamblièreBich-Tram Huynh

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