Risk factors for non-diabetic renal disease in diabetic patients

Clinical Kidney Journal
Sheila BermejoMaría José Soler

Abstract

Diabetic patients with kidney disease have a high prevalence of non-diabetic renal disease (NDRD). Renal and patient survival regarding the diagnosis of diabetic nephropathy (DN) or NDRD have not been widely studied. The aim of our study is to evaluate the prevalence of NDRD in patients with diabetes and to determine the capacity of clinical and analytical data in the prediction of NDRD. In addition, we will study renal and patient prognosis according to the renal biopsy findings in patients with diabetes. Retrospective multicentre observational study of renal biopsies performed in patients with diabetes from 2002 to 2014. In total, 832 patients were included: 621 men (74.6%), mean age of 61.7 ± 12.8 years, creatinine was 2.8 ± 2.2 mg/dL and proteinuria 2.7 (interquartile range: 1.2-5.4) g/24 h. About 39.5% (n = 329) of patients had DN, 49.6% (n = 413) NDRD and 10.8% (n = 90) mixed forms. The most frequent NDRD was nephroangiosclerosis (NAS) (n = 87, 9.3%). In the multivariate logistic regression analysis, older age [odds ratio (OR) = 1.03, 95% CI: 1.02-1.05, P < 0.001], microhaematuria (OR = 1.51, 95% CI: 1.03-2.21, P = 0.033) and absence of diabetic retinopathy (DR) (OR = 0.28, 95% CI: 0.19-0.42, P < 0.001) were independently...Continue Reading

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Citations

May 1, 2021·Journal of Clinical Medicine·Nestor Oliva-DamasoAndrew S Bomback
Jun 3, 2021·International Journal of Molecular Sciences·Domenico SantoroGiorgina Barbara Piccoli
Jul 3, 2021·Journal of Clinical Medicine·José María Mora-GutiérrezNuria Garcia-Fernandez
Jul 3, 2021·Journal of Clinical Medicine·Clara García-CarroMaría José Soler
Aug 3, 2021·International Journal of Nephrology·Francesco FontanaGianni Cappelli

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

GEENDIAB
GLOSEN
SPSS Statistics
GLOMCAT

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