Risk factors for nonvisualization of the sentinel lymph node on lymphoscintigraphy in breast cancer patients.

EJNMMI Research
Youssef ChahidJan Booij

Abstract

Accurate sentinel lymph node (SLN) staging is essential for both prognosis and treatment in patients with breast cancer. However, the preoperative lymphoscintigraphy may fail to visualize the SLN in some patients. The purpose of this retrospective study was to identify risk factors associated with SLN nonvisualization on lymphoscintigraphy. For this single-center retrospective study, all data of lymphoscintigraphy of SLN procedures from March 2011 to April 2021 were collected and reviewed from the Amsterdam UMC database. A total of 1886 SLN procedures were included in this study. The SLN nonvisualization rate was 25.1% on lymphoscintigraphy at 4 h post-injection. The SLN nonvisualization rate decreased to 9.4% after reinjection. Multivariable analysis showed that age ≥ 70 years (P < 0.001; OR: 2.27; 95% CI: 1.46-3.53), BMI ≥ 30 kg/m2 (P = 0.031; OR: 1.48; 95% CI: 1.04-2.12) and nonpalpable tumors (P = 0.004; OR: 1.54; 95% CI: 1.15-2.07) were independent predictors of SLN nonvisualization. Tumor location, brand of radiopharmaceutical, injected dose and volume, experience of preparer and administrator were not associated with SLN nonvisualization. None of the patient, tumor or tracer characteristics were associated with SLN nonvi...Continue Reading

References

Oct 1, 1998·The New England Journal of Medicine·D KragP Beitsch
Mar 14, 2001·Journal of the American College of Surgeons·P J TanisB B Kroon
May 11, 2002·European Journal of Nuclear Medicine and Molecular Imaging·P J TanisB B R Kroon
Jan 22, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Amit GoyalUNKNOWN ALMANAC Trialists Group
Mar 26, 2005·European Journal of Nuclear Medicine and Molecular Imaging·A H ChakeraB Hesse
Oct 3, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Francesco GiammarileSergi Vidal Sicart
Feb 6, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·B PouwM P M Stokkel
Feb 9, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M G NieblingH J Hoekstra
May 2, 2019·World Journal of Nuclear Medicine·John FreebodyMonica A Rossleigh

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