Risk factors for paraaortic lymph node metastasis in endometrial cancer

International Journal of Clinical Oncology
Mustafa Erkan SariTayfun Güngör

Abstract

The purpose of this study was to determine the risk factors for paraaortic lymph node (LN) metastasis in endometrial cancer (EC) patients who underwent comprehensive surgical staging. A total of 641 women with EC (endometrioid, non-endometrioid, or mixed histology) who underwent comprehensive surgical staging including pelvic and paraaortic LN dissection between 2008 and 2016 were included in this retrospective study. Patient data were analyzed with respect to paraaortic LN involvement, and predictive factors for paraaortic LN metastasis were investigated. Lymph node metastasis was detected in 90 (14%) patients, isolated pelvic LN metastasis in 28 (4.3%), isolated paraaortic LN metastasis in 15 (2.3%), and both pelvic and paraaortic LN metastasis in 47 (7.3%) women, respectively. Univariate analysis showed that the risk of paraaortic LN metastasis significantly increased in patients with non-endometrioid histology, age greater than 60 years, grade 3 tumor, deep myometrial invasion, lymphovascular space invasion (LVSI), primary tumor diameter (≥2 cm), cervical stromal invasion, adnexal involvement, serosal invasion, pelvic LN involvement, two or more positive pelvic LNs, and positive peritoneal cytology (p < 0.05). At the end of...Continue Reading

References

Aug 1, 1989·British Journal of Obstetrics and Gynaecology·J H Shepherd
Jan 12, 2000·Gynecologic and Obstetric Investigation·E KuceraG Breitenecker
Feb 15, 2000·Seminars in Radiation Oncology·M N Barnes, L C Kilgore
Jun 28, 2000·American Journal of Obstetrics and Gynecology·A MarianiK C Podratz
Sep 5, 2001·Gynecologic Oncology·D S McMeekinR Mannel
Feb 27, 2004·Gynecologic Oncology·Andrea MarianiKarl C Podratz
May 10, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H NomuraS Nozawa
Feb 3, 2007·Gynecologic Oncology·Yoh WatanabeUNKNOWN Disease Committee of Uterine Endometrial Cancer, Japanese Gynecologic Oncology Group
Nov 27, 2008·Journal of the National Cancer Institute·Pierluigi Benedetti PaniciCostantino Mangioni
Apr 7, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·William Creasman
Apr 16, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Sergio Pecorelli
Jun 16, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·D J O'BrienM Foley
Jun 15, 2011·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Taner TuranM Faruk Kose
Jan 25, 2014·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·C NumanogluB Guraslan
Feb 21, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Sokbom KangKi-Tae Kim
Mar 26, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Anna LuomarantaMikko Loukovaara
Feb 2, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ulas SolmazEmel Ebru Pala
Jun 13, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ricardo dos ReisPedro T Ramirez
Jan 10, 2016·Journal of Cancer Research and Clinical Oncology·Holm EggemannAtanas Ignatov

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Citations

Feb 23, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Salih TaşkinFirat Ortaç
Aug 23, 2019·Archives of Gynecology and Obstetrics·Yujie LiGuirong Sun
Oct 5, 2019·Nutrition and Cancer·Hengjie LiYong Nan
Feb 6, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Emre GünakanAli Ayhan
Apr 30, 2019·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Mehmet M MeydanliYaprak Engin-Ustun
Jan 30, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Yoo-Na KimSang Wun Kim
May 27, 2021·AJR. American Journal of Roentgenology·Christian K Pedersen, Aparna S Babu
Aug 12, 2021·The Journal of Obstetrics and Gynaecology Research·Serkan AkışEvrim Bostancı

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