PMID: 9544910Apr 17, 1998Paper

Risk factors for pediatric tuberculosis infection and disease after household exposure to adult index cases in Alaska

The Journal of Pediatrics
B D GessnerC M Nolan

Abstract

To determine risk factors for pediatric tuberculosis infection and active tuberculosis. We examined medical records from multiple sources for all 282 children younger than 15 years in Alaska during the period 1987 to 1994 who were household contacts of an adult with culture-positive pulmonary tuberculosis. Infection developed in 25% of the children and progressed to active disease in 9.6%. Risk factors for pediatric infection included exposure to a parent who had active tuberculosis and exposure to any adult with active tuberculosis who had a cough, smear positivity, or a left upper lobe (LUL) chest lesion (odds ratios, 2.1 to 2.8). Among the 71 children in whom infection developed, Alaska Natives and younger children were more likely to progress to active tuberculosis, as were children exposed to a parent who had active tuberculosis and children exposed to any adult who had a LUL chest lesion (odds ratios, 1.5 to 12). Although all children with household exposure to adults with active tuberculosis have a high risk of contracting the infection and disease, specific risk factors can be identified and differ for infection and disease. Alaska Natives have an increased risk of progression to disease once infected.

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Citations

Feb 12, 2008·American Journal of Respiratory and Critical Care Medicine·Khaoula AissaUNKNOWN CG94 Study Group
Feb 9, 2008·Emerging Infectious Diseases·Alan J ParkinsonTammy Zulz
Nov 29, 2015·Pediatric Clinics of North America·Caitlin Hansen, Elijah Paintsil
Aug 19, 2014·Revue de pneumologie clinique·M MjidM Beji
Apr 27, 2016·Revue de pneumologie clinique·A BerraiesA Hamzaoui
May 24, 2007·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Joseph Jacob NaniaThomas R Talbot
Aug 31, 2002·Pediatric Pulmonology·Fouad MadhiChristophe Delacourt
Sep 4, 2004·Revue des maladies respiratoires·A DeschildreJ Cadranel

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