PMID: 11913499Mar 27, 2002Paper

Risk factors for penicillin resistance and mortality in Korean adults with Streptococcus pneumoniae bacteremia

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
B N KimY S Kim

Abstract

A retrospective analysis was performed to measure the incidence of pneumococcal bacteremia and to identify risk factors for penicillin resistance and prognostic factors for outcome in adults. A total of 151 cases of pneumococcal bacteremia were identified from 149 adults during the period 1996-2000. The overall rate of penicillin resistance was 49%, ranging from 54.2% in 1996 to 48.5% in 2000 (P=0.93). Rates of resistance to ceftriaxone, clindamycin, erythromycin, and trimethoprim-sulfamethoxazole were 21.6%, 51%, 62%, and 44.7%, respectively. Multidrug resistance was documented in 47.7% of the cases. Penicillin resistance was significantly associated with solid tumor, biliary drainage catheter, and previous beta-lactam therapy in the univariate analysis. However, the associations were not as significant as independent risk factors in the multivariate analysis. Mortality was 23.8% and did not change significantly during the study period (P=0.06). Mortality rates in cases caused by penicillin-susceptible Streptococcus pneumoniae and penicillin-resistant Streptococcus pneumoniae were 23% and 24.7%, respectively (P=0.81). Mortality was not significantly influenced by penicillin resistance, even high-level resistance (24.4% vs. 20%...Continue Reading

Citations

Apr 14, 2006·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S E BeekmannG V Doern
Jul 12, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Victor L YuUNKNOWN International Pneumococcal Study Group
Apr 20, 2004·Critical Care Medicine·Christopher J Crnich, Richard A Proctor
Jul 30, 2011·The Pediatric Infectious Disease Journal·Peter NyasuluUNKNOWN Group for Enteric, Respiratory and Meningeal Diseases Surveillance in South Africa (GERMS-SA)
Oct 6, 2006·Journal of Clinical Microbiology·Heungsup SungGeorge M Eliopoulos
Jan 20, 2009·Diagnostic Microbiology and Infectious Disease·Seong-Ho ChoiYang Soo Kim
Feb 19, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Ivan Fan-Ngai HungRicardo Zotomayor
Jun 7, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A S LevinA A Barone

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