Abstract
To identify predisposing factors leading to corneal perforation in patients with microbial keratitis. Two groups of 60 patients each, with perforated corneal ulcers and healed/healing corneal ulcers, respectively, were recruited in a case-control study conducted in northern India. The cases and controls were matched by age and time of presentation. A standardised proforma was used to identify potential predisposing factors for demographic, social, medical, ocular, and treatment history. All participants underwent a detailed ocular examination. Corneal scrapings were performed where relevant. The characteristics associated with corneal perforation in microbial keratitis were outdoor occupation (p = 0.005), illiteracy (p = 0.02), excessive alcohol use (p = 0.03), history of "something falling into eye" (p = 0.003), trauma with vegetable matter (p = 0.008), vision less than counting fingers at referral (p<0.001), central location of ulcer (p<0.001), lack of corneal vascularisation (p<0.001), delay in starting initial treatment (p<0.001), failure to start fortified antibiotics (p<0.001), and monotherapy with fluoroquinolones (p = 0.002). The lack of corneal vascularisation (OR 6.4, 95% CI 4.2 to 13.5), delay in starting initial tre...Continue Reading
References
Feb 1, 1987·The British Journal of Ophthalmology·D J Coster, P R Badenoch
Oct 1, 1983·Archives of Ophthalmology·D C MuschR F Meyer
Oct 1, 1995·Archives of Ophthalmology·T P O'BrienP McDonnell
Nov 1, 1994·The British Journal of Ophthalmology·P CourtrightD J Divala
Dec 1, 1995·Ophthalmology·S D McLeodP J McDonnell
Aug 1, 1997·The British Journal of Ophthalmology·J P Whitcher, M Srinivasan
Mar 20, 1998·The British Journal of Ophthalmology·M SrinivasanJ P Whitcher
May 22, 1998·Archives of Ophthalmology·C S Moy
Jan 26, 1999·Ophthalmology·D Y KunimotoG N Rao
Jun 12, 1999·Ophthalmology·A I MiedziakE J Cohen
Dec 28, 1999·The British Journal of Ophthalmology·D Y KunimotoG N Rao
Jan 13, 2000·Cornea·R B VajpayeeN Sharma
Mar 24, 2000·The British Journal of Ophthalmology·N GangopadhyayH R Taylor
Feb 13, 2001·American Journal of Ophthalmology·P L MallariH Taylor
Mar 27, 2001·The British Journal of Ophthalmology·M P UpadhyayJ P Whitcher
Jun 26, 2001·The British Journal of Ophthalmology·F SchaeferY Guex-Crosier
Mar 28, 2002·Eye·R J C BowmanG J Johnson
Jul 26, 2002·The British Journal of Ophthalmology·T R G PooleA R C Ramsay
Oct 19, 2002·The British Journal of Ophthalmology·A K LeckG J Johnson
Jan 25, 2003·The British Journal of Ophthalmology·S J Tuft
Aug 21, 2003·The British Journal of Ophthalmology·T WongC N J McGhee
May 14, 2005·Toxicology·Judith SendzikRalf Stahlmann
Citations
May 29, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Marios ConstantinouRasik B Vajpayee
Oct 3, 2008·The British Journal of Ophthalmology·M SrinivasanN R Acharya
Jan 30, 2016·Eye·A MedsingeK K Nischal
Nov 29, 2011·Survey of Ophthalmology·Vishal JhanjiRasik B Vajpayee
Feb 6, 2008·Emergency Medicine Clinics of North America·Jorma B Mueller, Christopher M McStay
Jul 27, 2007·Clinical & Experimental Ophthalmology·Matthew D GreenFiona J Stapleton
Mar 3, 2015·Mycoses·László KredicsUNKNOWN Indo-Hungarian Fungal Keratitis Working Group
Nov 15, 2014·Seminars in Ophthalmology·Sameh S MandourHassan G Farahat
May 6, 2016·The British Journal of Ophthalmology·Giulio FerrariRoberta Mazzieri
Aug 10, 2016·The British Journal of Ophthalmology·Denise Loya-GarciaEnrique O Graue-Hernandez
Jul 21, 2011·Ocular Immunology and Inflammation·Jon D WenderEmmett T Cunningham
May 15, 2007·Current Opinion in Infectious Diseases·Philip Aloysius Thomas, Pitchairaj Geraldine
Dec 14, 2019·Ophthalmic Epidemiology·Simon ArungaMatthew J Burton
Dec 18, 2018·Journal of Current Ophthalmology·Anuradha RajRenu Dhasmana
Mar 28, 2018·Ophthalmic Epidemiology·Jaya Devi ChidambaramMatthew J Burton
Jan 11, 2017·Journal of Ophthalmology·Sloan W Rush, Ryan B Rush
Feb 25, 2020·Wellcome Open Research·Simon ArungaMatthew Burton
Apr 2, 2021·Clinical Ophthalmology·Tolcha Regasa DagoFekede Bekele Daba
Jun 8, 2021·Progress in Retinal and Eye Research·Romina Mayra Lasagni VitarGiulio Ferrari