PMID: 6401992Jan 1, 1983Paper

Risk factors for peripheral atherosclerosis. Retrospective evaluation by stepwise discriminant analysis

Arteriosclerosis : an Official Journal of the American Heart Association, Inc
E PilgerG M Kostner

Abstract

To evaluate the optimal discriminators for peripheral atherosclerosis, we studied retrospectively 49 male patients and 39 male controls between 40 and 60 years of age. In addition to hypertension, cigarette smoking, diabetes mellitus, and hyperuricemia, we determined the most common lipids, lipoproteins, and apolipoproteins. Highly significant differences of median values between patients and controls in decreasing order of magnitude were recorded for apo A-II/apo B, apo A-I/apo B, apo B, total cholesterol, and LDL-cholesterol. A retrospective classification of patients and controls under optimal conditions with one variable (apo A-I/apo B) yielded an error rate of 25%. We found that apolipoproteins were better discriminators for peripheral atherosclerosis than than were lipids or lipoprotein lipids. The application of a linear regression discriminant analysis including 29 variables greatly decreased the rate of error and increased the sensitivity and specificity of the classification. From 229 possible models, we used an economic selection strategy to sort out those which either gave the best segregation or were considered the most practicable. The optimal model with 14 variables gave an error rate of less than 5% for the grou...Continue Reading

References

Dec 16, 1978·Lancet·G V BradbyK W Walton
Jun 1, 1978·European Journal of Clinical Investigation·T IshikawaN E Miller
Jan 1, 1977·Annual Review of Biochemistry·J L Goldstein, M S Brown
Apr 1, 1978·Metabolism: Clinical and Experimental·J J AlbersW R Hazzard
Jul 1, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·C VerganiN Dioguardi
Mar 1, 1976·Annals of Internal Medicine·P F CohnW B Weglicki
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Apr 1, 1982·Atherosclerosis·G De BackerJ P Deslypere
Jan 1, 1982·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G FranceschiniC R Sirtori
Jul 1, 1981·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G FagerG Bondjers

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Citations

Jan 1, 1985·Rheumatology International·A UlreichF Rainer
Apr 1, 1991·Biological Psychiatry·H D Abraham, F H Duffy
May 30, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·G M KostnerP Pichler
May 1, 1990·Clinica Chimica Acta; International Journal of Clinical Chemistry·G M KostnerH Aicher
Nov 1, 1987·Journal of Affective Disorders·J A Ramos-BrievaF Cañas
Jun 10, 2014·Pattern Recognition Letters·Hu HuangGustavo K Rohde
May 1, 1985·Journal of the American College of Cardiology·J F RenA S Iskandrian
Oct 1, 1988·European Journal of Vascular Surgery·F G Fowkes
May 11, 1987·Nucleic Acids Research·C S Shelley, F E Baralle
Nov 1, 1990·Annals of Vascular Surgery·J H Rapp
Mar 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J D BrunzellP O Kwiterovich
Jul 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G HoeflerG M Kostner
Dec 28, 2007·The Journal of Biological Chemistry·Lawrence W CastellaniAldons J Lusis
Jan 13, 2005·Journal of Atherosclerosis and Thrombosis·Yoshihiko NoguchiYasushi Saito
Apr 1, 1986·Metabolism: Clinical and Experimental·R ZechnerG M Kostner

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