Risk factors for pertussis hospitalizations in Australians aged 45 years and over: A population based nested case-control study

Vaccine
Surendra KarkiBette Liu

Abstract

Although studies have described factors associated with pertussis hospitalization in children, data on adult hospitalization are sparse. We examined the association between patient characteristics and hospitalization among older adults with pertussis. We conducted a nested case-control study of participants in the 45 and Up prospective cohort in New South Wales, Australia, with an incident pertussis diagnosis during 2006-2012. Cases were defined as those with a hospitalization coded as 'whooping cough' or 'non-specific respiratory disease/cough' between a week prior and 6 weeks after the diagnosis of pertussis based on laboratory tests. Controls were participants diagnosed with pertussis but not hospitalized. Among 265,287 participants, the incidence of pertussis and pertussis hospitalization was 83.9 (95% [confidence interval] CI, 78.7-89.6) and 2.9 (95% CI, 2.1-4.1)/100,000 person-years, respectively. Among 33 cases and 882 controls, factors associated with hospitalization were increasing age (compared to those 45-54 years, adjusted odds ratio [aOR] 5.4 (95% CI, 1.6-18.2) and 8.9 (95% CI, 2.3-34.7) in those aged 65-74 years and 75+ years, respectively) and smoking (ever versus never, aOR 2.37 (95% CI, 1.11-5.06)). The risk of...Continue Reading

References

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Citations

Apr 17, 2020·Human Vaccines & Immunotherapeutics·Victoria A JenkinsWalid Kandeil
Jul 24, 2020·Human Vaccines & Immunotherapeutics·Julianne BaylissMichael Nissen
Apr 20, 2021·COPD·Emmanuel ArisPiyali Mukherjee
Jun 13, 2021·Infectious Diseases and Therapy·Denis Macina, Keith E Evans

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