Risk factors for poor outcomes of children with acute acalculous cholecystitis

Pediatrics and Neonatology
Yi-An LuChien-Chang Chen

Abstract

Acute acalculous cholecystitis (AAC) is generally considered to be a mild disease in children; however, if left untreated or treated without caution, AAC can lead to severe outcomes, such as death. The objectives of this study were to present the clinical features and identify the predictors of mortality in pediatric AAC. Patients diagnosed with AAC between 2005 and 2012 were enrolled. AAC was defined by the presence of fever and an echo-proven thickened gallbladder wall exceeding 4 mm. A poor health outcome was defined as death. Further information related to the demographics, clinical manifestations, laboratory results, ultrasound findings, and pathogens present in the AAC patients was also collected. Predictors of mortality were identified by association analyses and confirmed by multivariate logistic regression. A total of 147 pediatric AAC patients (male/female = 1.01, mean age = 5.2 years) were included in this retrospective study. The most common clinical presentation was an elevated C-reactive protein level (84%) followed by hepatomegaly (80%) and anorexia (78%). AAC in children was associated with various diseases, including infectious diseases (70%), systemic diseases (13%), and malignancy (11%). Fourteen of the 147 (...Continue Reading

Citations

Jun 28, 2019·International Journal of Clinical Practice·Katarzyna Mazur-MelewskaMagdalena Figlerowicz
Apr 13, 2019·BMJ Case Reports·Ana Sofia SimõesSandra Ferreira
Nov 30, 2018·World Journal of Gastroenterology : WJG·Dimitri Poddighe, Vitaliy Sazonov
Sep 15, 2020·Clinical Practice and Cases in Emergency Medicine·Robert LangenohlKyle Couperus
Feb 11, 2021·Pediatric Reports·Carlos Leganés VillanuevaSusana Boronat Guerrero

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