Risk factors for postoperative recurrence after primary bowel resection in patients with Crohn's disease

World Journal of Gastroenterology : WJG
Kwan Mo YangJin Cheon Kim

Abstract

To evaluate the risk factors for postoperative recurrence after primary bowel resection in a cohort of Korean Crohn's disease (CD) patients. This study included 260 patients with no history of previous bowel surgery who underwent primary surgery for CD between January 2000 and December 2010 at Asan Medical Center (Seoul, South Korea). The median follow-up period was 101 mo. During the follow-up period, 66 patients (25.4%) underwent a second operation for disease recurrence. At 1, 5 and 10 years after the first operation, the cumulative rate of surgical recurrence was 1.1%, 8.3% and 35.9% and clinical recurrence occurred in 1.2%, 23.6% and 68.1%, respectively. In multivariate analysis, undergoing an emergency operation was a significant risk factor for surgical recurrence-free survival (SRFS) [HR = 2.431, 95%CI: 1.394-4.240, P = 0.002], as were the presence of perianal disease after the first operation (HR = 1.715, 95%CI: 1.005-2.926, P = 0.048) and history of smoking (HR = 1.798, 95%CI: 1.088-2.969, P = 0.022). The postoperative use of anti-tumor necrosis factor (TNF) agents reduced SRFS risk (HR = 0.521, 95%CI: 0.300-0.904, P = 0.02). History of smoking, postoperative perianal disease and undergoing an emergency operation were...Continue Reading

References

Sep 1, 1991·Annals of Surgery·F MichelassiG E Block
May 1, 1990·Gastroenterology·L R SutherlandG Fick
Jul 1, 1995·Scandinavian Journal of Gastroenterology·P MunkholmV Binder
Mar 1, 1994·Gastroenterology·M CottoneL Pagliaro
May 1, 1998·Annals of Surgery·T M HeimannA H Aufses
Jan 15, 2000·Annals of Surgery·O BernellG Hellers
Dec 21, 2000·The British Journal of Surgery·O BernellG Hellers
Mar 23, 2002·Gastroenterology·David A SchwartzWilliam J Sandborn
Sep 2, 2003·Gastroenterology·UNKNOWN American Gastroenterological Association
Jul 5, 2005·World Journal of Gastroenterology : WJG·Takayuki Yamamoto
Sep 12, 2007·Archives of Internal Medicine·Dario SorrentinoStefania Maiero
Apr 22, 2008·The American Journal of Gastroenterology·Suk-Kyun YangKyuyoung Song
Jun 10, 2008·Diseases of the Colon and Rectum·Jonathan T UnkartDavid W Dietz
Sep 3, 2008·International Journal of Colorectal Disease·George E ReeseParis P Tekkis
Dec 27, 2008·Gastroenterology·Miguel RegueiroScott E Plevy
Mar 19, 2009·World Journal of Gastroenterology : WJG·Hugh James Freeman
Apr 1, 2009·Inflammatory Bowel Diseases·Suk-Kyun YangKyuyoung Song
Jan 1, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S RissF Herbst
Jun 22, 2010·Scandinavian Journal of Gastroenterology·Byong Duk YeJin-Ho Kim
Dec 3, 2010·Journal of Crohn's & Colitis·Gert Van AsscheUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Mar 16, 2011·Journal of Digestive Diseases·Chuan Hua YangShu Dong Xiao
Aug 1, 2012·Scandinavian Journal of Gastroenterology·Xiang GaoPin-Jin Hu
Feb 5, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Guillaume BouguenLaurent Peyrin-Biroulet
Jun 7, 2013·Diseases of the Colon and Rectum·Stefan RissAnton Stift
Aug 29, 2013·Techniques in Coloproctology·S RissA Stift
Oct 24, 2014·World Journal of Gastroenterology : WJG·Tara M Connelly, Evangelos Messaris
Feb 7, 2016·Journal of Gastroenterology and Hepatology·Yoo Min HanHyun Chae Jung

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Citations

Aug 9, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·L W UngerS Riss
Mar 22, 2019·Current Drug Targets·Marjorie ArgolloSilvio Danese
Nov 13, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·R BolckmansB George
Nov 7, 2019·World Journal of Gastrointestinal Pharmacology and Therapeutics·Ze-Xian ChenPing Lan
May 8, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Lena W Y ThinMarina H Wallace
Nov 18, 2020·Clinics and Research in Hepatology and Gastroenterology·Clementine RiaultMathurin Fumery
May 6, 2021·Journal of Digestive Diseases·Kwangwoo NamSeok Won Jung

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Methods Mentioned

BETA
surgical resection
surgical recurrence

Software Mentioned

SPSS

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