PMID: 9188381Dec 1, 1996Paper

Risk factors for premature coronary heart disease after successful liver transplantation in adults

Journal of Transplant Coordination : Official Publication of the North American Transplant Coordinators Organization (NATCO)
S L Smith

Abstract

As solid-organ transplantation has evolved into a highly effective treatment for end-stage organ disease, the long-term health implications of chronic exposure of recipients to immunosuppressants and other pharmacological agents are becoming more apparent. Coronary heart disease has long been known to plague kidney transplant recipients and more recently has been found to affect heart transplant recipients disproportionately. Coronary heart disease after liver transplantation, however, is less well known. The purpose of this study was to examine risk factors for premature coronary heart disease in asymptomatic adult recipients of liver transplants. Nutrition-related risk factors for coronary heart disease (obesity and hyperlipidemia) were measured in 29 patients before and after liver transplantation. Changes with respect to primary immunosuppression protocol (cyclosporine plus corticosteroid vs tacrolimus plus corticosteroid) were compared. Risk factors that had not been present before transplantation were apparent in both groups by 6 months after transplantation. Although obesity and hyperlipidemia were not found to be independent risk factors for coronary heart disease, they were clinically important when considered in combi...Continue Reading

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Feb 15, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·C ManzarbeitiaS J Munoz
May 30, 2002·American Journal of Surgery·John M RabkinAli J Olyaei
Dec 10, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Sammy SaabMyron J Tong

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