Risk Factors for Preoperative Seizures and Loss of Seizure Control in Patients Undergoing Surgery for Metastatic Brain Tumors

World Neurosurgery
Adela WuKaisorn L Chaichana

Abstract

Metastatic brain tumors are the most common brain tumors in adults. Patients with metastatic brain tumors have poor prognoses with median survival of 6-12 months. Seizures are a major presenting symptom and cause of morbidity and mortality. In this article, risk factors for the onset of preoperative seizures and postoperative seizure control are examined. Adult patients who underwent resection of one or more brain metastases at a single institution between 1998 and 2011 were reviewed retrospectively. Of 565 patients, 114 (20.2%) patients presented with seizures. Factors independently associated with preoperative seizures were preoperative headaches (P = 0.044), cognitive deficits (P = 0.031), more than 2 intracranial metastatic tumors (P = 0.013), temporal lobe location (P = 0.031), occipital lobe location (P = 0.010), and bone involvement by tumor (P = 0.029). Factors independently associated with loss of seizure control after surgical resection were preoperative seizures (P = 0.001), temporal lobe location (P = 0.037), lack of postoperative chemotherapy (P = 0.010), subtotal resection of tumor (P = 0.022), and local recurrence (P = 0.027). At last follow-up, the majority of patients (93.8%) were seizure-free. Thirty patients ...Continue Reading

References

Sep 1, 1993·Neurology·P A Forsyth, J B Posner
Mar 1, 1997·International Journal of Radiation Oncology, Biology, Physics·L GasparR Byhardt
Jul 3, 2007·Clinical Neurology and Neurosurgery·Laura M LynamJames A Wilkens
Oct 21, 2011·Current Oncology Reports·Lakshmi NayakPatrick Y Wen
May 7, 2013·Clinical Neurology and Neurosurgery·Dorothea MillerIbrahim Erol Sandalcioglu
Sep 28, 2013·Neurological Research·Kaisorn Lee ChaichanaAlfredo Quinones-Hinojosa
Sep 28, 2013·Neurological Research·Kaisorn L ChaichanaAlfredo Quinones-Hinojosa
Dec 25, 2013·Handbook of Clinical Neurology·Jaime Gállego Pérez-Larraya, Jerzy Hildebrand
Dec 5, 2015·Journal of Neurosurgery·Dario J EnglotMichael W McDermott
Mar 8, 2016·Handbook of Clinical Neurology·Dario J EnglotCharles J Vecht

❮ Previous
Next ❯

Citations

Sep 10, 2019·Neuro-oncology·Fabian WolpertMichael Weller
Jul 1, 2018·Journal of Neuro-oncology·Abdurrahman I IslimMichael D Jenkinson
Feb 9, 2020·Current Treatment Options in Neurology·Roberta RudàAlessia Pellerino
Nov 28, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P RothUNKNOWN ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Oct 24, 2019·Journal of the Neurological Sciences·Jonah FoxEkrem Kutluay
Jan 29, 2021·Neuro-oncology Advances·Yahya AhmadipourRamazan Jabbarli
Dec 20, 2019·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Shaun AjinkyaEkrem Kutluay

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.