Risk Factors for Recurrent Lumbar Disc Herniation: A Systematic Review and Meta-Analysis

Medicine
Weimin HuangXiuchun Yu

Abstract

Recurrent lumbar disc herniation (rLDH) is a common complication following primary discectomy. This systematic review aimed to investigate the current evidence on risk factors for rLDH.Cohort or case-control studies addressing risk factors for rLDH were identified by search in Pubmed (Medline), Embase, Web of Science, and Cochrane library from inception to June 2015. Relevant results were pooled to give overall estimates if possible. Heterogeneity among studies was examined and publication bias was also assessed.A total of 17 studies were included in this systematic review. Risk factors that had significant relation with rLDH were smoking (OR 1.99, 95% CI 1.53-2.58), disc protrusion (OR 1.79, 95% CI 1.15-2.79), and diabetes (OR 1.19, 95% CI 1.06-1.32). Gender, BMI, occupational work, level, and side of herniation did not correlate with rLDH significantly.Based on current evidence, smoking, disc protrusion, and diabetes were predictors for rLDH. Patients with these risk factors should be paid more attention for prevention of recurrence after primary surgery. More evidence provided by high-quality observational studies is still needed to further investigate risk factors for rLDH.

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Oct 13, 1998·The Journal of Bone and Joint Surgery. British Volume·G CinottiF Postacchini
Dec 1, 1998·JAMA : the Journal of the American Medical Association·J Zhang, K F Yu
Apr 8, 2003·The Journal of Bone and Joint Surgery. British Volume·Ann M MøllerAnne Munksgaard
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Apr 28, 2004·Toxicon : Official Journal of the International Society on Toxinology·Deniz Yildiz
Aug 28, 2004·The Journal of Bone and Joint Surgery. British Volume·K A JanssonP Blomqvist
Sep 7, 2004·Neurosurgical Focus·Karin R Swartz, Gregory R Trost
Oct 19, 2004·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Bilge KaraUmit Acar
Mar 29, 2006·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Yasuhiro NemotoHirosi Oda
Oct 3, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Corey S GillRick W Wright
Nov 23, 2006·JAMA : the Journal of the American Medical Association·James N WeinsteinRichard A Deyo
Jun 1, 2007·The New England Journal of Medicine·Wilco C PeulUNKNOWN Leiden-The Hague Spine Intervention Prognostic Study Group
Aug 4, 2007·Minimally Invasive Neurosurgery : MIN·J M KimS T Lim
Nov 7, 2007·Joint, Bone, Spine : Revue Du Rhumatisme·Erick LegrandUNKNOWN Spine Section of the French Society for Rheumatology
Mar 30, 2010·The Spine Journal : Official Journal of the North American Spine Society·Dennis S MeredithStephen Lyman
Jun 3, 2010·Journal of Neurosurgery. Spine·Jennifer A MoliternoJohn A Boockvar
Dec 20, 2012·Journal of Spinal Disorders & Techniques·Shinji MiwaHiroyuki Tsuchiya
Sep 21, 2013·Asian Journal of Neurosurgery·Mohammad ShimiaAfshin Habibzadeh
Aug 5, 2014·Journal of Spinal Disorders & Techniques·Kyoung-Tae KimYoung-Baeg Kim
Mar 26, 2015·The New England Journal of Medicine·Allan H Ropper, Ross D Zafonte

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Citations

Oct 6, 2017·Current Reviews in Musculoskeletal Medicine·Raj M AminBrian J Neuman
Oct 19, 2019·International Orthopaedics·Tianhang XieYueming Song
Dec 14, 2018·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Ioannis D GelalisAnastasios V Korompilias
Aug 18, 2018·BMC Musculoskeletal Disorders·Wen Jie ChoyRalph J Mobbs
Sep 19, 2019·Surgical Neurology International·M DobranM Iacoangeli
Nov 10, 2018·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Ioannis D GelalisAnastasios V Korompilias
Dec 15, 2020·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Alessandro SiccoliVictor E Staartjes
Jan 15, 2021·The Spine Journal : Official Journal of the North American Spine Society·Bertrand DebonoHans D de Boer
Mar 1, 2020·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Tomohiro BannoYukihiro Matsuyama
Jan 12, 2021·Curēus·Gina N Guglielmi, Jason M Seibly
Nov 24, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Muhammad Fahmi Abdul JalilAli Ghahreman
Apr 15, 2021·World Journal of Clinical Cases·Zhi-Xiang ChengXiang-Rui Wang
Jun 9, 2021·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Garrett K HaradaHoward S An

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Methods Mentioned

BETA
glycosylation

Software Mentioned

Stata
Sciatica

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