PMID: 20135833Feb 6, 2010Paper

Risk factors for recurrent urinary tract infections in a cohort of patients with primary vesicoureteral reflux

The Pediatric Infectious Disease Journal
Cristiane S DiasEduardo A Oliveira

Abstract

Knowledge of risk of urinary tract infection (UTI) recurrence in vesicoureteral reflux (VUR) can help clinicians make therapeutic decisions. The aim of this retrospective cohort study was to identify risk factors associated with recurrent urinary tract infection in children with VUR. In addition, a risk score that might predict the chance of UTI recurrence was also proposed. Between 1970 and 2007, 740 patients were diagnosed with VUR and were systematically followed up at a single tertiary Renal Unit. Recurrent UTI was defined as more than 1 episode during follow-up. A binary logistic regression model was applied to identify variables independently associated with recurrent UTIs. During follow-up, information was obtained on 58,856 person-months. Recurrent UTIs occurred in 120 (16.2%) patients. The overall incidence rate of UTI was 8.4 episodes per 1000 person-months (95% CI, 7.7, 9.2). After adjustment by multivariable analysis, 5 variables were independent predictors of recurrent UTI: UTI as clinical presentation, age < 6 months, female gender, dysfunctional elimination syndrome, and severe grade of reflux. The risk for recurrent UTI was classified as low in 24% of children, medium in 42%, and high in 34%. UTI incidence rates...Continue Reading

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Citations

Mar 8, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·George M Wadie, Kevin P Moriarty
Aug 1, 2013·Journal of Pediatric Urology·Catherine J BradshawRowena Hitchcock
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Dec 5, 2017·The Journal of Urology·Zhan Tao WangAntoine Khoury
Jul 5, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hye Sun HyunHee Gyung Kang
Oct 5, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Stephen YangPaul Austin

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