Risk factors for refractory anastomotic strictures after oesophageal atresia repair: a multicentre study

Archives of Disease in Childhood
Floor W T VergouweDCEA Study Group

Abstract

To determine the incidence of refractory anastomotic strictures after oesophageal atresia (OA) repair and to identify risk factors associated with refractory strictures. Retrospective national multicentre study in patients with OA born between 1999 and 2013. Exclusion criteria were isolated fistula, inability to obtain oesophageal continuity, death prior to discharge and follow-up <6 months. A refractory oesophageal stricture was defined as an anastomotic stricture requiring ≥5 dilations at maximally 4-week intervals. Risk factors for development of refractory anastomotic strictures after OA repair were identified with multivariable logistic regression analysis. We included 454 children (61% male, 7% isolated OA (Gross type A)). End-to-end anastomosis was performed in 436 (96%) children. Anastomotic leakage occurred in 13%. Fifty-eight per cent of children with an end-to-end anastomosis developed an anastomotic stricture, requiring a median of 3 (range 1-34) dilations. Refractory strictures were found in 32/436 (7%) children and required a median of 10 (range 5-34) dilations. Isolated OA (OR 5.7; p=0.012), anastomotic leakage (OR 5.0; p=0.001) and the need for oesophageal dilation ≤28 days after anastomosis (OR 15.9; p<0.001) w...Continue Reading

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Citations

Sep 7, 2019·Journal of Pediatric Gastroenterology and Nutrition·Floor W T VergouweHanneke IJsselstijn
Nov 26, 2019·Journal of Pediatric Gastroenterology and Nutrition·Peter D NgoMichael A Manfredi
Jul 9, 2020·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Olugbenga AwolaranG Suren Arul
Jul 11, 2020·European Journal of Pediatrics·Yi-Hsuan LuHung-Chieh Chou
Apr 20, 2019·Nature Reviews. Disease Primers·Marinde van LennepMichiel P van Wijk
Oct 8, 2020·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·Sofie Örnö AxMichaela Dellenmark-Blom
Jul 7, 2020·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·Mustafa O OztanAbdullah Yildiz
Jun 21, 2021·Journal of Cardiothoracic Surgery·Jin-Xi HuangChaoming Zhou
Jul 8, 2021·Journal of Pediatric Surgery·Camille E van HoornJ Marco Schnater

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