PMID: 9423580Jan 10, 1998Paper

Risk factors for sensitisation to methyltetrahydrophthalic anhydride

Occupational and Environmental Medicine
K YokotaK Morimoto

Abstract

To examine an association between specific IgE to methyltetrahydrophthalic anhydride (MTHPA) and exposure time, atopic history, smoking habits, and total IgE concentrations. A cross sectional survey was carried out on a population of 148 workers from two condenser plants using epoxy resin with MTHPA, an acid anhydride curing agent known to cause allergy. Using a Pharmacia CAP system with a MTHPA human serum albumin conjugate, specific IgE antibody was detected in serum from 97 (66%) out of the 148 workers exposed to MTHPA. Stepwise multiple linear regression analysis showed a striking relation between log concentrations of specific and total IgE (P < 0.0001). Furthermore, when the workers were divided into two groups according to a cut-off point (100 IU/ml) between low and high total IgE, current smoking was significantly (P = 0.025) associated with specific IgE production only in the group with low total IgE (< 100 IU/ml). Smoking is the most significant risk factor for raising specific IgE to MTHPA in the group with low total IgE concentrations.

References

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Nov 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H WelinderS Skerfving
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Oct 1, 1996·Environmental Health and Preventive Medicine·K YokotaK Morimoto

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Citations

Jul 24, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K YokotaK Morimoto
Sep 13, 2003·Sangyō eiseigaku zasshi = Journal of occupational health·Naomi MatsumotoToshiyuki Takakura

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