Risk factors for sexual dysfunction in BRCA mutation carriers after risk-reducing salpingo-oophorectomy

Menopause : the Journal of the North American Menopause Society
Jessica L ChanS M Domchek

Abstract

The aim of the study was to identify risk factors for sexual dysfunction in BRCA mutation carriers who have undergone risk-reducing salpingo-oophorectomy (RRSO). A cross-sectional study was performed. BRCA1/2 mutation carriers with and without RRSO were surveyed to determine sexual function (Female Sex Function Index [FSFI]), demographics, medical history, sleep quality, depression, and anxiety scores. Characteristics of patients with the lowest quartile of FSFI scores (<14 ± 8.8) were analyzed to identify risk factors for the most severe phenotype. In the 804 women surveyed, 764 underwent RRSO. Of the 529 (69%) carriers with completed FSFI questionnaires in the RRSO cohort, sexual dysfunction was reported in 77.3%. Poor sleep (P = 0.002), hot flashes (P = 0.002), lack of current systemic hormone therapy (HT) use (P = 0.002), depression (P < 0.001), and anxiety (P = 0.001) were associated with sexual dysfunction. In adjusted analyses, depression (adjusted odds ratio [aOR] 2.4, 95% CI, 1.4-4.1) and hot flashes (aOR 1.9, 95% CI, 1.2-3.0) remained significantly associated with sexual dysfunction. Depression was also a significant risk factor for the most severe degree of sexual dysfunction (OR 2.1, 95% CI, 1.3-3.5) and had the gre...Continue Reading

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Dec 19, 2018·Menopause : the Journal of the North American Menopause Society·Lisa Larkin, Sheryl A Kingsberg
Oct 16, 2019·Menopause : the Journal of the North American Menopause Society·Martha HickeyMichelle Peate
Oct 1, 2019·Menopause : the Journal of the North American Menopause Society·Martha HickeyMichelle Peate
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Aug 29, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H JiangJ D Wark
Aug 23, 2019·Climacteric : the Journal of the International Menopause Society·R A SzaboM Hickey
Jun 23, 2020·Hormone Molecular Biology and Clinical Investigation·Lydia Marie-ScemamaJean Marc Ayoubi
Nov 1, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Annabelle BrennanMartha Hickey

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