Abstract
The aim of the study was to identify risk factors for sexual dysfunction in BRCA mutation carriers who have undergone risk-reducing salpingo-oophorectomy (RRSO). A cross-sectional study was performed. BRCA1/2 mutation carriers with and without RRSO were surveyed to determine sexual function (Female Sex Function Index [FSFI]), demographics, medical history, sleep quality, depression, and anxiety scores. Characteristics of patients with the lowest quartile of FSFI scores (<14 ± 8.8) were analyzed to identify risk factors for the most severe phenotype. In the 804 women surveyed, 764 underwent RRSO. Of the 529 (69%) carriers with completed FSFI questionnaires in the RRSO cohort, sexual dysfunction was reported in 77.3%. Poor sleep (P = 0.002), hot flashes (P = 0.002), lack of current systemic hormone therapy (HT) use (P = 0.002), depression (P < 0.001), and anxiety (P = 0.001) were associated with sexual dysfunction. In adjusted analyses, depression (adjusted odds ratio [aOR] 2.4, 95% CI, 1.4-4.1) and hot flashes (aOR 1.9, 95% CI, 1.2-3.0) remained significantly associated with sexual dysfunction. Depression was also a significant risk factor for the most severe degree of sexual dysfunction (OR 2.1, 95% CI, 1.3-3.5) and had the gre...Continue Reading
References
May 1, 1989·Psychiatry Research·D J BuysseD J Kupfer
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Dec 1, 1993·Journal of Psychosomatic Obstetrics and Gynaecology·J Nathorst-BöösK Carlström
Sep 5, 1998·International Clinical Psychopharmacology·J Angst
Feb 18, 1999·JAMA : the Journal of the American Medical Association·E O LaumannR C Rosen
Apr 27, 2000·Journal of Sex & Marital Therapy·R RosenR D'Agostino
Sep 7, 2000·The New England Journal of Medicine·J L ShifrenN A Mazer
Apr 5, 2003·American Journal of Human Genetics·A AntoniouD F Easton
Apr 26, 2003·Gynecologic Oncology·Mark RobsonKenneth Offit
May 13, 2003·Current Medical Research and Opinion·Mireille BonierbaleJean Tignol
Oct 24, 2003·Familial Cancer·L ElitS Narod
Oct 25, 2003·Science·Mary-Claire KingUNKNOWN New York Breast Cancer Study Group
Sep 10, 2004·Menopause : the Journal of the North American Menopause Society·Lorraine DennersteinVictor W Henderson
Oct 16, 2004·Archives of Sexual Behavior·Jill M CyranowskiLynda H Powell
Apr 22, 2005·Journal of Sex & Marital Therapy·Markus WiegelRaymond Rosen
Oct 13, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Timothy R RebbeckUNKNOWN PROSE Study Group
Mar 9, 2006·American Journal of Obstetrics and Gynecology·Cynthia M FarquharAlistair W Stewart
Aug 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joanna B MadalinskaNeil K Aaronson
Nov 8, 2006·Journal of Women's Health·Krista KotzLorraine Dennerstein
Feb 13, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Noah D KauffTimothy R Rebbeck
Sep 25, 2008·Journal of the National Cancer Institute·Andrea EisenUNKNOWN Hereditary Breast Cancer Clinical Study Group
Jan 15, 2009·Gynecologic Oncology·Carolyn Y FangMary B Daly
Jun 11, 2009·Journal of Clinical Psychopharmacology·Sidney H Kennedy, Sakina Rizvi
Sep 3, 2010·JAMA : the Journal of the American Medical Association·Susan M DomchekTimothy R Rebbeck
Sep 21, 2010·Familial Cancer·Danielle Campfield BonadiesEllen T Matloff
Jan 11, 2011·Gynecologic Oncology·A FinchS A Narod
Apr 3, 2012·The Journal of Sexual Medicine·Evan Atlantis, Thomas Sullivan
May 31, 2012·American Journal of Clinical Oncology·Michael DeSimoneDon S Dizon
Nov 6, 2013·JAMA Surgery·David B SarwerNicholas J Christian
Jan 8, 2014·The Oncologist·Don S DizonSusanne McIlvenna
Feb 26, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amy P M FinchSteven A Narod
Jan 1, 1997·International Journal of Psychiatry in Clinical Practice·D S BaldwinJ Birtwistle
Aug 3, 2014·Obesity Surgery·Vasileios EfthymiouKonstantinos Assimakopoulos
Sep 6, 2014·Journal of the National Comprehensive Cancer Network : JNCCN·Mary B DalyUNKNOWN National comprehensive cancer network
Mar 13, 2015·Iranian Red Crescent Medical Journal·Mosayeb MozafariFatemeh Najafi
Feb 4, 2016·American Journal of Clinical Oncology·Nicole BirrerDon S Dizon
Citations
Dec 19, 2018·Menopause : the Journal of the North American Menopause Society·Lisa Larkin, Sheryl A Kingsberg
Oct 16, 2019·Menopause : the Journal of the North American Menopause Society·Martha HickeyMichelle Peate
Oct 1, 2019·Menopause : the Journal of the North American Menopause Society·Martha HickeyMichelle Peate
Oct 28, 2019·Psycho-oncology·C Bethan PowellTina Raine-Bennett
Aug 29, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H JiangJ D Wark
Aug 23, 2019·Climacteric : the Journal of the International Menopause Society·R A SzaboM Hickey
Jun 23, 2020·Hormone Molecular Biology and Clinical Investigation·Lydia Marie-ScemamaJean Marc Ayoubi
Nov 1, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Annabelle BrennanMartha Hickey
Feb 16, 2021·Gynecologic Oncology·Martha HickeyHadine Joffe
Feb 4, 2021·Menopause : the Journal of the North American Menopause Society·Giovanni GrandiFabio Facchinetti
Mar 20, 2021·Menopause : the Journal of the North American Menopause Society·Rakibul M IslamMartha Hickey
Aug 21, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Victoria KershawSwati Jha