Risk factors for stroke on left ventricular assist devices

Journal of Cardiac Surgery
Muath BishawiCarmelo Milano

Abstract

Patients with end-stage heart failure on left ventricular assist devices (LVADs) are predisposed to a high incidence of stroke. Preoperative factors associated with increased stroke risk are poorly understood. We performed a single-center retrospective review of all patients from 2009 to 2014 in whom a rotary flow LVAD was implanted. All patients with symptoms of a cerebrovascular event underwent a non-contrast head computed tomography scan. Logistic regression was used to determine factors associated with stroke both on univariate and multivariable analysis. A total of 390 patients were retrospectively analyzed and of those 61 (15.6%) had a stroke at an average follow-up of 3.5 ± 1.6 years. The majority were male (72%) and were treated a priori as destination therapy (73%). The proportion of patient receiving a centrifugal flow pump was 23% compared to 77% receiving an axial flow pump. For those patients who experienced a stroke and then died, the average time from stroke to death was 158 ± 296 days. Of the 61 patients who had a stroke, 38 (62%) died (P < 0.001 compared to death rate without a stroke). On Cox regression analysis, a history of cerebrovascular accident (CVA), hyperlipidemia, and history of venous thromboembolism...Continue Reading

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Citations

Aug 3, 2018·Journal of Cardiac Surgery·Harold L Lazar
Dec 28, 2018·Circulation·Paolo C ColomboDouglas A Horstmanshof
Aug 9, 2018·Journal of Cardiac Surgery·Olga N KislitsinaClyde W Yancy
Dec 7, 2021·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Kohei TonaiTomoyuki Fujita

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