Risk factors for subtherapeutic levels of posaconazole tablet

The Journal of Antimicrobial Chemotherapy
Laura A TangAnthony J Perissinotti

Abstract

Posaconazole is the prophylactic antifungal of choice for patients with haematological malignancies at high risk of invasive fungal infections (IFIs). Studies have demonstrated that subtherapeutic concentrations of posaconazole are associated with breakthrough fungal infections and specific risk factors for subtherapeutic troughs associated with the suspension formulation have been identified. However, these risk factors have not been evaluated in a large patient population with the recently approved tablet formulation. To determine the risk factors for subtherapeutic posaconazole troughs associated with the tablet formulation in patients receiving posaconazole as IFI prophylaxis. From 1 February 2013 to 31 March 2015 all posaconazole serum trough concentrations were evaluated. A total of 157 patients receiving posaconazole tablet for prophylaxis during induction therapy for haematological malignancies and allogeneic stem cell transplant recipients with graft-versus-host disease were included for analysis. Overall, 28 patients (18%) had subtherapeutic troughs (<700 ng/mL). Patients were more likely to have subtherapeutic troughs if they had diarrhoea (n = 24; 83%) (P < 0.001), were receiving a proton pump inhibitor (n = 27; 93%...Continue Reading

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Citations

Jul 31, 2019·Antimicrobial Agents and Chemotherapy·Elodie Gautier-VeyretFrançoise Stanke-Labesque
Jun 2, 2020·Expert Opinion on Drug Metabolism & Toxicology·Ruth Van DaeleJohan Maertens
Jun 4, 2019·Clinical Transplantation·Saima AslamUNKNOWN AST Infectious Disease Community of Practice
Jan 24, 2021·Molecular and Cellular Endocrinology·Katharina R Beck, Alex Odermatt
Feb 4, 2021·Drug Delivery and Translational Research·Valentina AndrettoGiovanna Lollo
Apr 2, 2021·The Journal of Infection·Peijun Yvonne ZhouLay Hoon Andrea Kwa
Apr 23, 2021·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Emily A HighsmithTodd W Canada
May 22, 2021·Infectious Disease Clinics of North America·Julie M Steinbrink, Marisa H Miceli
May 28, 2021·Current Opinion in Infectious Diseases·Julien CoussementMonica Slavin
May 20, 2021·Current Opinion in Infectious Diseases·Russell E Lewis, David R Andes
Sep 28, 2021·Antimicrobial Agents and Chemotherapy·Adam J DiPippoDimitrios P Kontoyiannis
Dec 23, 2021·Internal Medicine Journal·Benjamin W TehUNKNOWN Australasian Antifungal Guidelines Steering Committee
Dec 20, 2021·Therapeutic Drug Monitoring·Benjamin KablyEliane M Billaud

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