Risk factors for surgical site infections and assessment of vancomycin powder as a preventive measure in patients undergoing first-time cranioplasty

Journal of Neurosurgery
Kingsley O Abode-IyamahJeremy Greenlee

Abstract

OBJECTIVE Craniectomy is often performed to decrease intracranial pressure following trauma and vascular injuries. The subsequent cranioplasty procedures may be complicated by surgical site infections (SSIs) due to prior trauma, foreign implants, and multiple surgeries through a common incision. Several studies have found that intrawound vancomycin powder (VP) is associated with decreased risk of SSIs after spine operations. However, no previously published study has evaluated the effectiveness of VP in cranioplasty procedures. The purpose of this study was to determine whether intrawound VP is associated with decreased risk of SSIs, to evaluate VP's safety, and to identify risk factors for SSIs after cranioplasty among patients undergoing first-time cranioplasty. METHODS The authors conducted a retrospective cohort study of adult patients undergoing first-time cranioplasty for indications other than infections from January 1, 2008, to July 31, 2014, at an academic health center. Data on demographics, possible risk factors for SSIs, and treatment with VP were collected from the patients' electronic health records. RESULTS During the study period, 258 patients underwent first-time cranioplasties, and 15 (5.8%) of these patients ...Continue Reading

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Citations

Jun 22, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Paolo FrassanitoGiancarlo Scoppettuolo
Jan 10, 2020·The Journal of Craniofacial Surgery·Tamir ShayChad R Gordon
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Jul 1, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Emilio Jiménez-MartínezMiquel Pujol
Oct 14, 2020·Neurosurgical Review·Jennifer GöttscheMichael Hahn
Oct 15, 2021·Antimicrobial Resistance and Infection Control·Emilio Jiménez-MartínezMiquel Pujol

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