Risk Factors for Survival After Heart Transplantation in Children and Young Adults: A 22-Year Study of 179 Transplants

World Journal for Pediatric & Congenital Heart Surgery
Shawn ShahJeffrey P Jacobs

Abstract

This article reviews all patients who underwent heart transplantation (HTx) within a single institution (172 patients underwent 179 HTx [167 first-time HTxs, 10 second HTxs, 2 third HTxs]) to describe diagnostic characteristics, management protocols, and risk factors for mortality. Descriptive analysis was performed for the entire cohort using mean, standard deviation, median, interquartile range, and overall range, as appropriate. Univariable and multivariable Cox proportional hazards models were performed to identify prognostic factors for outcomes over time. The primary outcome of interest was mortality, which was modeled by Kaplan-Meier analysis. Median age at HTx was 263 days (range, 5 days to 24 years; mean = 4.63 ± 5.95 years; 18 neonates, 79 infants). Median weight at HTx was 7.5 kg (range, 2.2-113 kg; mean = 19.36 ± 23.54). Diagnostic categories were cardiomyopathy (n = 62), primary transplantation for hypoplastic left heart syndrome (HLHS) or HLHS-related malformation (n = 33), transplantation after cardiac surgery for HLHS or HLHS-related malformation (n = 17), non-HLHS congenital heart disease (n = 55), and retransplant (n = 12). Operative mortality was 10.1% (18 patients). Cumulative total follow-up is 1,355 years....Continue Reading

References

Jul 13, 2004·Cardiology in the Young·Robert J BoucekAlfred Asante-Korang
Oct 30, 2004·The Annals of Thoracic Surgery·Jeffrey P JacobsGeorge R Daicoff
Apr 25, 2006·The Annals of Thoracic Surgery·Jeffrey Phillip JacobsUNKNOWN Joint EACTS-STS Congenital Database Committee
Nov 23, 2006·Cardiology in the Young·Jeffrey Phillip JacobsRobert J Boucek
Feb 5, 2008·The Journal of Thoracic and Cardiovascular Surgery·Vladimiro L VidaFrancis Fynn-Thompson
Apr 30, 2008·The Annals of Thoracic Surgery·Jeffrey P JacobsJames A Quintessenza
Mar 29, 2011·The Annals of Thoracic Surgery·Jeffrey Phillip JacobsJames Anthony Quintessenza
Dec 14, 2011·Cardiology in the Young·Alfred Asante-KorangJohn Sleasman
May 29, 2012·The Annals of Thoracic Surgery·Rochus K VoellerCharles B Huddleston
Jun 27, 2013·World Journal for Pediatric & Congenital Heart Surgery·David M OvermanDavid M Shahian
Dec 3, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Alfred Asante-KorangJeffrey P Jacobs
Jan 18, 2018·The Annals of Thoracic Surgery·Jeffrey P JacobsMarshall L Jacobs
Feb 14, 2018·Circulation·Jane W NewburgerUNKNOWN Pediatric Heart Network Investigators

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Citations

Dec 12, 2018·Xenotransplantation·Jeffrey L PlattMarilia Cascalho
Jan 8, 2021·World Journal for Pediatric & Congenital Heart Surgery·Genevieve C TuiteJeffrey P Jacobs
Jun 30, 2021·The Annals of Thoracic Surgery·Mark S BleiweisJeffrey P Jacobs

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Methods Mentioned

BETA
flow cytometry
biopsies
biopsy

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