PMID: 15333252Aug 31, 2004Paper

Risk factors for the deterioration of glucose metabolism in polycystic ovary syndrome

Reproductive Biomedicine Online
Jim X Wang, R J Norman

Abstract

Women with polycystic ovary syndrome (PCOS) have a high risk of abnormal glucose metabolism, which deteriorates gradually over time. This study was designed to assess contributing factors to the rate of deterioration of glucose metabolism over the 4- to 7-year follow-up period. The study group included 67 PCOS women who had normal glucose tolerance in the initial test in 1990-1992. There was a significant increase in both fasting and 2-h glucose concentrations, and body weight, over the follow-up period. The initial obesity, expressed as waist:hip ratio and BMI, was significantly related to the increase of glucose concentrations, while weight gain was not a significant factor. The overweight/obese PCOS women have a faster deterioration of glucose metabolism over the follow-up period than the non-obese ones. Moderate weight gain has no significant detrimental effect on the rate of deterioration of glucose metabolism.

References

Sep 28, 1995·The New England Journal of Medicine·S Franks
Jun 1, 1996·Journal of Psychosomatic Obstetrics and Gynaecology·C GalletlyF Blaney

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Citations

Feb 18, 2010·Reproductive Biomedicine Online·Bulent O YildizHakan Yarali
Jul 3, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jana VrbikovaGiovanni Pacini
Jan 7, 2011·Biology of Reproduction·Fatima HernandezMarta Tesone
Mar 26, 2005·Human Reproduction Update·J Vrbíková, D Cibula
Aug 9, 2005·Human Reproduction·J VrbíkováJ Skrha

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