Risk factors for the development of bronchiolitis obliterans in children with bronchiolitis

Thorax
Alejandro J ColomG B Diette

Abstract

Bronchiolitis obliterans (BO) is an uncommon and severe form of chronic obstructive lung disease in children that results from an insult to the lower respiratory tract. A case-control study of children under the age of 3 years was performed in 109 cases and 99 controls to determine risk factors for the development of BO. Participants were evaluated by immunofluorescence viral tests, pulmonary function tests, and questions to assess tobacco and other exposures. Bronchiolitis due to adenovirus (odds ratio (OR) 49, 95% confidence interval (CI) 12 to 199) and the need for mechanical ventilation (OR 11, 95% CI 2.6 to 45) were strongly and independently associated with an increased risk for BO. Factors not associated with post-infectious BO included age of the child, sex, and environmental tobacco exposure (either in utero or during infancy). Adenovirus infection and need for mechanical ventilation are significant risk factors for developing BO in children. Further research is needed to determine why these risk factors are so strong and how they may contribute to the development of the disease.

References

Dec 1, 1992·Acta Paediatrica·A S MistchenkoS Grinstein
May 1, 1990·The American Review of Respiratory Disease·J P HanrahanF E Speizer
Jan 1, 1986·American Journal of Diseases of Children·R C WelliverN McCarthy
Jan 1, 1988·The American Review of Respiratory Disease·P HiattR S Tepper
Mar 1, 1988·Chest·K A HardyN Zaeri
Oct 1, 1984·Archives of Disease in Childhood·P D SlyH Newton-John
Jun 4, 1999·The Journal of Pediatrics·A M TeperS M Vidaurreta
Nov 26, 1999·Journal of Paediatrics and Child Health·R Massie, D Armstrong
May 2, 2000·Pediatric Pulmonology·L ZhangF A Abreu e Silva
Apr 17, 2002·American Journal of Respiratory and Critical Care Medicine·Ah-Fong HooJanet Stocks
Feb 1, 2003·Lancet·Liao PinhuMark Griffiths

❮ Previous
Next ❯

Citations

May 27, 2008·Intensive Care Medicine·Etienne JavouheyDaniel Floret
Jan 11, 2014·The Lancet Infectious Diseases·Elizabeth D LowenthalRashida A Ferrand
Apr 5, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rashida A FerrandElizabeth L Corbett
May 14, 2008·Current Opinion in Pediatrics·Siby P Moonnumakal, Leland L Fan
Jan 7, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Andrea MoscatelliPietro Tuo
Sep 15, 2007·Journal of Paediatrics and Child Health·Chih-Yung ChiuTzou-Yien Lin
Jan 20, 2011·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Mónica Siminovich, Patricia Murtagh
May 17, 2011·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Vaibhav KeskarSandeep B Bavdekar
Feb 20, 2013·Revue des maladies respiratoires·J de BlicT Chinet
Jan 24, 2012·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·O SardónJ Korta
Aug 30, 2011·Allergologia et immunopathologia·F De Baets
Nov 27, 2010·Paediatric Respiratory Reviews·Gilberto B FischerJose A Castro-Rodriguez
Dec 8, 2009·Pediatric Clinics of North America·Gregory J Redding, Catherine A Byrnes
Feb 13, 2015·Intractable & Rare Diseases Research·Silvia Onoda Tomikawa, Joaquim Carlos Rodrigues
Nov 3, 2015·Annals of the American Thoracic Society·Kai RyuYutaka Sugita
Jul 24, 2007·Journal of Emergency Nursing : JEN : Official Publication of the Emergency Department Nurses Association·Kerry C Willis
Sep 12, 2015·Jornal de pediatria·Luiz Vicente Ribeiro Ferreira da Silva FilhoRenato T Stein
Sep 12, 2015·Jornal de pediatria·Jose Dirceu Ribeiro, Gilberto Bueno Fischer
Aug 16, 2014·Orphanet Journal of Rare Diseases·Silvia Onoda TomikawaJoaquim Carlos Rodrigues
Oct 16, 2009·Pediatric Pulmonology·Alejandro J Colom, Alejandro M Teper
Feb 28, 2008·Pediatric Pulmonology·Salvatore CazzatoAlessandro Cicognani
Oct 19, 2011·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·William A McEwanLeo C James
Mar 18, 2011·The Clinical Respiratory Journal·Zak CallawayChang-Keun Kim
Jan 1, 2014·Pediatric Pulmonology·Luiz Felipe FrohlichDanilo C Berton
May 17, 2014·Acta Paediatrica·Jose A Castro-RodriguezPatricia Murtagh
Nov 22, 2014·Thorax·Paul Cullinan, Andrew Bush
Dec 6, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·P R BarreroA S Mistchenko
Jul 8, 2016·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Rita MattielloLeonardo Araújo Pinto
Jul 4, 2017·Pediatric Pulmonology·David G HancockKevin D Forsyth
Feb 26, 2019·Expert Review of Respiratory Medicine·Ema Kavaliunaite, Paul Aurora
Oct 25, 2013·Journal of Child Health Care : for Professionals Working with Children in the Hospital and Community·Alison PeelerSue Kildea
Apr 14, 2016·British Journal of Hospital Medicine·Siba P PaulJayesh M Bhatt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.