Risk factors for the development of distant metastases in patients undergoing pelvic lymphadenectomy for prostatic cancer

American Journal of Surgery
J D SchmidtR Garcia-Reyes


Sixty-two patients with clinically localised prostatic cancer underwent pelvic lymphadenectomy between 1972 and 1975. Thirty-one patients had concomitant total prostatectomy. The objectives of this study included determination of the relation of findings at lymphadenectomy, with and without total prostatectomy, to subsequent clinical course, identification of histologic parameters related to the subsequent appearance of distant metastatic disease, and determination of the vital status of patients initially having a staging pelvic lymphadenectomy. Follow-up of at least 5 years was obtained for 52 patients, including 28 who had concomitant total prostatectomy. Ten patients were lost to follow-up. Fifty-four percent are alive with metastatic disease 10 percent have died with metastatic disease, 10 percent have died with metastatic cancer, and 12 percent have died without prostate cancer. Metastases have developed in 11 (37 percent) of 30 patients with negative pelvic lymph nodes, reflecting either seminal vesicle or transcapsular invasion. Minimal lymph node involvement (one or two pelvic nodes) alone may not be as poor a prognostic sign as originally thought. Metastases have developed in 22 percent of nine patients with tumor con...Continue Reading


Jun 1, 1997·The Prostate·X GaoK V Honn
Dec 16, 1998·The American Journal of Surgical Pathology·L ChengD G Bostwick
Jan 1, 1994·International Journal of Radiation Oncology, Biology, Physics·S A LeibelW F WHITMORE
Dec 1, 1984·Urology·P GuinanK Mouli
Feb 1, 1993·Cancer·J D SchmidtA Bartolucci
Aug 1, 1987·Cancer·J T GrayhackJ M Kozlowski
Mar 1, 1996·Seminars in Surgical Oncology·I S Gill
Aug 1, 1985·The Journal of Urology·O G van AubelF H Schröder

Related Concepts

Carcinoma, Cribriform
Lymph Node Dissection
Lymphatic Metastasis
Neoplasm Metastasis
Neoplasm Recurrence, Local
TNM Staging System
Prostatectomy, Suprapubic
Malignant Neoplasm of Prostate
Relative Risk

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