Risk Factors for the Development of Stent-Associated Cholangitis Following Endoscopic Biliary Stent Placement

Digestive Diseases and Sciences
Brendan T EverettRichard S Zubarik

Abstract

To elucidate the overall risk and risk factors for developing cholangitis following biliary stent placement by endoscopic retrograde cholangiopancreatography (ERCP) and to determine the clinical outcomes of these individuals. We performed a retrospective review of 796 patients who had undergone 1127 ERCPs with biliary stent placement between 2007 and 2015 at a single tertiary care center. There were 91 episodes of stent-associated cholangitis (SAC) during the study period. Data obtained through the medical records included ERCP indication, patient factors (biliary anatomy, demographics, and comorbidities), stent characteristics (material, length, and design), change in serum bilirubin, stent indwelling time, rates and etiologies of bacteremia, and the mortality rate. Those with SAC were more likely to have an anatomic biliary stricture (13.1% vs. 2.3%, p < .0001), with hilar and multiple strictures having the highest risk (19.1% vs. 11.6%, p = .04). The ERCP indication of malignant biliary obstruction was associated with higher rates of SAC (15.6% vs. 3.4%, p = < .0001). Rates of SAC were higher in those who failed to normalize total bilirubin (16.9% vs. 7.8%, p = .0005), and these episodes occurred earlier compared to those wh...Continue Reading

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Apr 7, 2020·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Tsuyoshi HamadaKazuhiko Koike
May 25, 2021·Gastroenterology Clinics of North America·Zhibo AnNadav Sahar

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