Risk factors for the development of hypermagnesemia in patients prescribed magnesium oxide: a retrospective cohort study

Journal of Pharmaceutical Health Care and Sciences
Eri WakaiMasahiro Okuda

Abstract

Magnesium oxide (MgO), an antacid and laxative, is widely used in Japan to treat constipation and peptic ulcers. Because serum Magnesium (Mg) levels are elevated in elderly and/or patients with renal failure, its periodic monitoring is recommended for patients prescribed MgO, in order to prevent MgO-induced hypermagnesemia. However, there is little information regarding the factors contributing to the development of MgO-induced hypermagnesemia. In the present study, we retrospectively investigated the risk factors of hypermagnesemia in patients prescribed MgO. Data of 3258 patients hospitalized in Mie University Hospital between October 2015 and September 2017, who were prescribed MgO tablets, were extracted from the electronic medical records. According to the inclusion and exclusion criteria, 320 of the 3258 patients were enrolled in this study. Hypermagnesemia was defined as serum Mg levels ≥2.5 mg/dL (by the Common Terminology Criteria for Adverse Events version 4.0). Uni- and multivariate analyses were performed to identify risk factors for the development of hypermagnesemia in patients prescribed MgO using the following variables: age, estimated glomerular filtration rate, blood urea nitrogen levels, MgO dose, duration of...Continue Reading

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Citations

Aug 6, 2019·Journal of Clinical Biochemistry and Nutrition·Hideki MoriMasahiro Kikuchi
Sep 4, 2019·Drugs & Aging·Lisa G PontKylie Williams
Feb 3, 2021·Nutrients·Hideki MoriHidekazu Suzuki

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