Risk factors for thrombophilia in young adults presenting with thrombosis.

International Journal of Hematology
Osman YokusGulsum Ozet

Abstract

The increased risk for thrombosis is known as hypercoagulability or thrombophilia. Here, we investigated risk factors for thrombophilia which were screened in young adult patients presenting with thrombotic events or with recurrent abortions with unknown etiology. A total of 115 patients aged between 16 and 50 years who were found to harbor thrombophilia were retrospectively evaluated. The laboratory investigations performed for the assessment of thrombophilia included protein C, protein S, antithrombin III deficiencies, activated protein C resistance, factor V Leiden (FVL), prothrombin 20210A (PT 20210) and methylenetetrahydrofolate reductase (MTHFR) gene mutations, factor VIII elevation, lupus anticoagulant and antiphospholipid antibodies (APA). In 66% of the cases a single thrombophilic defect was identified while some of the patients had combined thrombophilic defects. The most common thrombophilic defect was mutation in the MTHFR gene, and was followed by FVL mutation, the presence of APA and PT 20210 gene mutation, respectively. The patients were divided into two different age groups, 16-35 and 36-50 years, and arterial thrombosis was more common in the older age group. Our results indicated that some important thrombophi...Continue Reading

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Citations

Dec 24, 2011·Genetic Testing and Molecular Biomarkers·Rouba HoteitRami A R Mahfouz
Jun 20, 2014·Annals of the Rheumatic Diseases·Savino SciasciaUNKNOWN APS Action
Sep 20, 2011·Translational Research : the Journal of Laboratory and Clinical Medicine·Charles J GlueckPing Wang
May 26, 2012·Journal of Clinical Laboratory Analysis·Samira HadhriHadef Skouri

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Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

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