Risk Factors for Tumor Recurrence Following Primary Intravenous Chemotherapy (Chemoreduction) for Retinoblastoma in 869 Eyes of 551 Patients.

Journal of Pediatric Ophthalmology and Strabismus
Lauren A DalvinCarol L Shields

Abstract

To identify risk factors for retinoblastoma recurrence following chemoreduction. This was a retrospective review of patients with retinoblastoma treated from 1994 to 2019 using chemoreduction with analysis for recurrence using Kaplan-Meier, Cox regression, and logistic regression. There were 869 eyes of 551 patients with retinoblastoma treated with chemoreduction. Follow-up in 556 eyes revealed main solid tumor recurrence (n = 355, 64%), subretinal seed recurrence (n = 244, 44%), vitreous seed recurrence (n = 162, 29%), and/or new tumor (n = 118, 21%) requiring management with focal therapy (transpupillary thermotherapy, cryotherapy) (n = 294, 53%), intra-arterial chemotherapy (n = 125, 22%), intravitreal chemotherapy (n = 36, 6%), plaque radiotherapy (n = 120, 22%), external beam radiotherapy (n = 57, 10%), and/or enucleation (n = 49, 9%). Of all recurrences, 62% were detected by 1 year, 86% by 2 years, 94% by 3 years, 98% by 5 years, 99% by 10 years, and 100% by 15 years. Risk factors for recurrence on multivariate analysis included younger patient age at presentation (odds ratio [OR] = 1.02 [1.00 to 1.04] per 1 month decrease, P = .02), greater International Classification of Retinoblastoma group (OR = 1.24 [1.05 to 1.47] pe...Continue Reading

References

Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ruth A KleinermanJoseph F Fraumeni
Sep 26, 2006·Ophthalmology·Carol L ShieldsJerry A Shields
Oct 12, 2007·Drugs·Jonathan W KimIra J Dunkel
Mar 11, 2009·Archives of Ophthalmology·Carol L ShieldsJerry A Shields
Feb 16, 2011·Archives of Ophthalmology·Y Pierre GobinDavid H Abramson
Jul 24, 2013·American Journal of Ophthalmology·Aparna RamasubramanianCarol L Shields
Nov 19, 2013·Pediatric Blood & Cancer·Guillermo L ChantadaJulio Manzitti
Jul 30, 2014·American Journal of Ophthalmology·Hans E Grossniklaus
Sep 4, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeannette R WongRuth A Kleinerman
May 25, 2016·Cancer Control : Journal of the Moffitt Cancer Center·Pia R Mendoza, Hans E Grossniklaus
Jan 18, 2017·Ophthalmic Genetics·David H AbramsonY Pierre Gobin
Mar 26, 2019·International Ophthalmology Clinics·Jesse L BerryJonathan W Kim

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Citations

Feb 22, 2021·International Ophthalmology·Swathi KalikiAshik Mohamed
Jun 5, 2021·European Journal of Ophthalmology·İrem KoçSepideh Lotfisadigh

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