Risk factors for urinary tract infections due to ciprofloxacin-resistant Escherichia coli in a tertiary care urology department in Switzerland

Swiss Medical Weekly
Joëlle NicolettiRainer Weber

Abstract

Monitoring of antimicrobial resistance is a key component of antibiotic stewardship programs. In 2007, a significantly higher resistance rate of Escherichia coli to ciprofloxacin was found at the Department of Urology, University Hospital Zurich, Switzerland, when compared to other hospital units. Thus, we aimed to determine the risk factors for this increased fluoroquinolone resistance in outpatients and inpatients with urinary tract infection (UTI) or colonisation with E. coli. We performed a cross sectional study including 275 patients of the Department of Urology in whom E. coli was isolated from urine or blood cultures between 01.01.2006 and 31.08.2007. Clinical data were collected from patients' records using a structured questionnaire. Multivariable analysis was performed for the detection of risk factors. Ciprofloxacin-resistant E. coli was detected in 22% of patients. Risk factors for ciprofloxacin-resistant E. coli included prior use of fluoroquinolones (odds ratio [OR] (95% confidence intervals): 2.24 (1.08-4.62), p = 0.030), prior urinary tract catheterisation (OR: 2.41 (1.02-5.67), p = 0.044) and recurrent UTIs (OR: 2.26 (1.07-4.78), p = 0.032). 60.8% of all prescriptions in urinary tract infections were for fluoro...Continue Reading

Citations

Oct 26, 2012·Interdisciplinary Perspectives on Infectious Diseases·Axel Dalhoff
Aug 16, 2011·The American Journal of Geriatric Pharmacotherapy·S James Matthews, Jason W Lancaster
Jul 22, 2011·Current Opinion in Pharmacology·Andrew J StewardsonStephan Harbarth
Aug 26, 2015·The American Journal of Emergency Medicine·Lara KratochwillArvind Venkat

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