Risk Factors for Venous Thromboembolism Among Reproductive Age Women

Journal of Women's Health
Carolyn L WesthoffAndrew Eisenberger

Abstract

Venous thromboembolism (VTE) is rare among young women and is often presumed to occur in the setting of a genetic predisposition or during the use of estrogen-containing combined hormonal contraceptive or to have an unknown cause. This study aims to describe the distribution of VTE risk factors among women with a confirmed VTE. We identified all women aged 15-46 years with a VTE diagnosis at Columbia University Medical Center from 2005 to 2012 using medical center databases. We then reviewed all electronic medical records to validate the diagnoses and identify risk factors associated with each confirmed case. We identified 315 cases and confirmed 186 (59%). The proportion of unconfirmed cases increased over time. Forty percent of confirmed cases were associated with hormonal contraceptives or pregnancy. Ninety-five percent of confirmed cases had identifiable major risk factors including a personal history, family history, malignancy or other predisposing illness, recent long-haul travel, trauma, hospitalization, and obesity; many had multiple simultaneous risk factors. None of the confirmed cases was associated with a previously known genetic predisposition, but in 10 confirmed cases a genetic predisposition was identified duri...Continue Reading

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Citations

Feb 22, 2017·Obstetrical & Gynecological Survey·Kathleen M AntonyJ Igor Iruretagoyena

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Methods Mentioned

BETA
contraception

Software Mentioned

Eclipsys SunriseXA
WebCIS
SAS

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